Archive for February 2014

Bodybuilding IGF-1

Insulin like growth factor-1 (IGF-1) is a substance which in manufactured by recombinant DNA technology. IGF-1 is the primary mediator of the growth promoting effects of human growth hormone. As such, the substance also can stimulate the growth of bone, muscle, and internal organs. Its effects on skeletal muscle are also highly hyperplasic, meaning it causes an increase in cell number. Unlike human growth hormone, however, this substance has very strong insulin like effects. It can support growth by increasing the uptake of amino acids, glucose, and fatty acids, but lowers blood sugar levels so efficiently that it can induce severe hypoglycemia if to high of a dose is taken. The increased uptake of fatty acids may also mean that the drug can increase the amount of body fat that is stored by the users. The United States FDA approved the medical use of IGF-1 in 2005. It is sold under the brand name of Increlex manufactured by the pharmaceutical company Tercica Inc. Tercica licenses this technology from Genentech, which was the first company to sell synthetic human growth hormone in the United States.

The effect of muscle hyperplasia that IGF1 can help promote is the primary reason why it has become so popular among bodybuilders. It is believed that IGF1 may be able to produce localized growth in the muscles that the IGF1 is administered into post-workout. However this effect of the hormone remains more theoretical in nature because of the lack of research available on the subject using human subjects. Despite this many users still claim that they have seen results from IGF1 when using it for this explicit purpose and it remains within the realm of possibilities. However simply because science can not discount the result as implausible does not mean that it is a given either. Among the other anabolic effects that IGF1 can produce in the body are things such as increasing protein synthesis, increasing nitrogen retention, as well as inducing the growth of more muscle fibers. When an appropriate amount of amino acids (protein) is available, all of these actions within the body are able to be completed. It has been demonstrated that IGF1 can help to improve collagen production as well as the reproduction of cartilage in joints.

The hormone has also been shown to exhibit the ability to act as a neuro-protector and promoter mainly because IGF1 receptors are located in the tissue of the brain. It has been demonstrated that there is a potential for when supplemented with IGF1 a decrease in the progress of some brain diseases can be brought about as well as slowing the deterioration of brain function in some elderly subjects. However similar findings or any evidence of improved brain function or capacity has not been demonstrated in young, healthy individuals. Obviously by helping to promote these anabolic mechanisms for growth IGF1 also acts as an anti-catabolic. This would be beneficial to those users in a calorie deficit or in other circumstances that place them at risk of losing muscle mass. IGF1 also has the ability to positively affect lipolysis in users if other necessary conditions are met, namely proper diet and training protocols. When combined with the ability to preserve muscle mass, IGF1 appears to be an attractive choice for those that are attempting to decrease their body fat while maintaining as much of their muscle mass as possible.

IGF1 is composed of seventy amino acids, the same number as insulin. As stated earlier, it is primarily secreted by the liver. The stimulus that is responsible for this secretion is the presence of growth hormone. In fact IGF1 is primarily the causal connection between growth hormone and its anabolic and anti-catabolic capabilities. This is not to say that effects caused by growth hormone could be produced with only IGF1, but rather that the two compounds are very much related to one another and both are needed for optimal tissue growth.

In terms of dosing for IGF-1, users have reported seen good results when administering dosing ranging from 100 to 160 mcg per day. This total dose would be split into several injections, most of which would likely be administered post-workout.

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Melanotan II

Melanotan II was developed originally as potential preventative treatments for various forms of skin cancer. It was thought that by artificially stimulating the internal tanning process among members of the population that were at high risk to develop skin cancer due to sun exposure that one may be able to lower the chances of these individuals from developing the disease later in life. While these findings have been relatively inconclusive in terms of the original intent of the product a few secondary uses for the drug have been found and are now utilized by many.

The main purpose that both Melanotan and Melanotan II are now administered for is their ability to act as a tanning agent. Both are synthetic hormones that once introduced into the body are able to cause a reaction within it that is similar to the natural tanning process that one goes through without the risks or need for sunlight to be present, while remembering that some of the benefits of exposure to the sun will also not be present. Along with the benefits of providing a tan without the need for extensive exposure to sunlight as well as improved sexual performance and/or desire, Melanotan II also may help to decrease the appetite via targeting an appetite-suppression receptor in the brain. This effect is not an overwhelming one but is noticeable for the majority of users and desirable for many. The duration of the tanning effect of the drug once a user ceases administering it will once again depend on several factors. The majority of users however will notice that the tan achieved with the drug will fade and become unnoticeable within four to eight weeks after ceasing the administration of the drug.

The libido enhancement and sexual performance benefits will fade much quicker along with the appetite suppressing effect. The tan that is created is considered a “natural” one in both the reaction that causes it in the body as well as the outward appearance of the skin once the drug has taken full effect. It should be noted however that to achieve the full effect of the hormones one will still have to expose themselves to sunlight and/or artificial tanning beds, etc. Unlike Melanotan however, Melanotan II has libido and sexual performance enhancing capabilities. This is due to Melanotan II having the metabolite Bremelanotide. Bremelanotide is currently under research as a possible treatment for various forms of sexual dysfunction, including both sexual arousal disorders as well as erectile dysfunction. Since however Bremelanotide has not been made available for use by the general public, for those wanting to reap its benefits in terms of its sexual performance improvements, Melanotan II is the only option at this point. It is believed that the source of this improvement in both sexual performance and arousal is the action of the hormone on the hypothalamus of the user. This, however, is still a theory in need of further investigation.

For most individuals, during the loading phase with the hormone, a range of between 0.015 to 0.02 milligrams per kilogram of body weight per injection should be sufficient. These injections would take place anywhere from twice daily to as infrequently as once every other day or longer. For the maintenance phase many individuals will find that a dose of approximately 0.01 milligrams per kilogram of body weight administered once every few days should be sufficient to maintain the effects of the hormone. As stated however, the reactions to Melanotan II are highly individualized so experimentation when first using this hormone will be necessitated. As always, lower doses should be utilized to begin with and increased as needed and as one is able to gage their tolerance for the drug.

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