Archive for February 2015

Bodybuilding peptide MGF MECHANO GROWTH FACTOR



MGF (mechano growth factor) has been used by bodybuilders and athletes for a few years already. After resistance exercise, IGF-1 is released within the muscle. Specifically, at this time, immediately following the mechanical use of a muscle, the IGF-I gene is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. It does so both by activating muscle stem cells and satellite cells, but also via various other anabolic processes. (1) It differs from “regular” IGF-1 mainly due to it’s C-Terminal sequence.


It was first discovered in the muscle by Goldspink, et al. In human muscle, a 49-base insert changes the reading frame in mechano growth factor (MGF) as compared to IGF-1.

What does MGF do?

When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary anabolic mechanism by which the body produces new muscle. MGF is available as an injectable peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.

From Studies done on MGF

In a rodent study, a single intramuscular injection into muscle resulted in a 25% increase in mean muscle fibre cross section area within three weeks. Using a similar protocol, liver-derived IGF-1 took four months to produce a 15% increase.

It would also appear that with regards to age, the young have a better ability to respond to MGF (4), and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.

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Uses of Ipamorelin peptide in bodybuilding:

Uses of Ipamorelin peptide in bodybuilding:

Ipamorelin is described to be the safest, cleanest of the GHRP’s. It’s similar to Hexarelin, but “cleaner”. There are no spikes in cortisol or prolactin. It’s known to decrease body fat, improves sleep and mood, speeds up recovery, and has many anti age benefits.

What is the averge dose of Ipamorelin
The average dosing for Ipamorelin is 200-300mcg two to three times daily.

How is Ipamorelin used?
Subcutaneous injection is the preferred method of taking Ipamorelin.

How long do I use Ipamorelin?
You can use Ipamorelin for up to a twelve week cycles

Can you explain how to Reconstitute or mix Ipamorelin?
Once you have an amount chosen, we can move on the the actual reconstitution. In this example, we will reconstitute with 2ml of bac water.

Snap of off the plastic cover of your peptide vial and your bacteriostatic water.

Take an alcohol wipe, and wipe down the rubber top of both the peptide vial and your bacteriostatic water, and then discard the wipe and allow vials to dry for a second or two.

Take a syringe and remove the safety cap (most will have one cap over the needle, and one over the plunger). Set these caps aside, while taking precaution not to expose your needle to any other object (it is sterile!).
Pull the plunger on your syringe to the maximum reading (will usually be either 1/2cc or 1cc) to allow the syringe to fill with air. (It is also common practice to draw this air from the peptide vial. You can do this by inserting the needle into the peptide vial, keeping it right side up, and drawing the air that way. Then pull the syringe from the bottle.

Insert the needle into the rubber portion (the septum) of your bacteriostatic water. With the syringe inserted, turn the vial of bacteriostatic water upside down, and push the plunger into the syringe (this will cause the air to enter the vial). Then, slowly, draw back on the syringe back to that maximum reading, as it will allow the syringe to fill with bac water.

Quick Note: The reason you fill your syringe with air, and then insert the air into the vial, is to keep the pressure within the vial, which will allow you to draw with much greater ease.

You may now turn the vial of back water back to right side up, and remove your syringe, again taking caution to avoid the needle from coming into contact with anything else.

You are now ready to insert the bac water into the peptide vial. I recommend reconstituting slowly, and avoiding adding the bac water directly onto the peptide, and rather down the sides of the vial. Take your peptide vial, and insert the syringe through the rubber stopper on an angle, enough so that once the needle penetrates the rubber, it is angled towards the side of the vial.

Slowly push down on the plunger allowing the bac water to enter down the sides of the vial. Take your time doing this, as there is no rush.

Once all of the bac water is into the vial, remove the syringe and gently (GENTLY!) swirl the vial allowing the peptide to dissolve into the bac water.

Depending on the target amount of bac water to be added, and the size of your pin, you must now repeat steps 3-8 until you have added the correct amount of bacteriostatic water. If you are aiming for 2ml of bacteriostatic water, and are using a 1/2cc syringe, this process must be done a total of 4 times, and if using a 1cc syringe, this process must be done a total of twice.

Once the proper amount is added, place the caps back on both ends of your syringe and properly discard of it. Do not reuse this syringe for injection.

Ipamorelin side effects most reported are as follows

Most users will find the common side effect of a head rush-like feeling and slight headaches. It is suggested that users start supplementation at a lower dose and work their way up. In addition, it is best to inject Ipamorelin 30-45 minutes before working out so that the user is getting the double benefit of both growth hormones working together to maximize results.

Ipamorelin is most commonly used (stacked) with
Using ipamorelin with a GHRH like CJC w/out DAC will give the user the biggest increase in GH and IGF-1 as GHRP’s and GHRH’s work together synergetically.
Storing your Ipamorelin after its been reconstituted

Once reconstituted with bacteriostatic water, the vials must be stored in a cool dry place like your refrigerator.

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