The rotator cuff musculature imparts dynamic stability to the glenohumeral joint. In particular, the balance between the subscapularis anteriorly and the infraspinatus posteriorly, often referred to as the rotator cuff “force couple,” is critical for concavity compression and concentric rotation of the humeral head.
Our goal was to determine the effect of pentadecapeptide BPC 157 on rotator cuff tear injury in rat model. 48 rats underwent detachment of the supraspinatus and infraspinatus and were randomly assigned to control and pentadecapeptide BPC 157 group.
BPC 157 animals were regularly treated with pentadecapeptide BPC 157 (10µg/kg) intraperitoneally, control animals got equivalent volume of saline. Animals were observed during experiment and were sacrificed 2, 4, 8 and 12 weeks after the surgery. Macroscopic observation (muscle atrophy (m(non-operated m triceps)/m-operated(m triceps)), movement range, front leg length) and functional analysis (walk pattern (SFI), front limb muscle strength (weightlifting time) were performed. In animals treated with pentadecapeptide BPC 157 was observed total functional recovery similar to healthy animals, along with supraspinate and infraspinate tendon healing.
In controls, mobility rage, muscle strength, and leg length were reduced compared to pentadecapeptide BPC 157 treated animals.
In conclusion, pentadecapeptide BPC 157 could be successfully used in healing and functional recovery of rotator cuff tear injury
Thymosin Beta 4 was first found in the thymus gland. Thymosin is typically found in both skeletal and smooth muscle. Thymosin Beta 4 is upregulated when the body experiences tissue damage. When a trauma injury occurs, the body releases Thymosin Beta 4 to heal from the trauma. Thymosin prevents adhesions from occurring, minimising scar tissue.
Benefits of Thymosin Beta 4 (TB-500)
Rapid Injury Repair and Recovery
Tissue repair and regeneration
Increases Muscle Growth
Improves Muscle Tone
Increases Strength and Endurance
Promotes Hair Growth
Relaxed muscle spasm
Increases the exchange of substance between cells
Stretches connective tissue
Minimises Scar Tissue Formation
Helps Maintain Flexibility
Promotes New Blood Cell Growth
Promotes Cell Differentiation
Prevents formations of adhesions and fibrous bands in muscles, tendons and ligaments
Thymosin beta 4 will now be tested as a potential treatment for HIV, AIDS & Influenza virus
Mechanism of Action for Thymosin Beta 4 (TB 500):
Thymosin Beta 4 is a hormone secreted from the thymus, in which the primary function is to stimulate the production of T-cells. T cells are a very important part of the immune system.
thymosineffectsThymosin also contributes to the development of B cells into plasma cells to produce antibodies.
Thymosin Beta four is a first-in-class naturally occurring peptide present in virtually all human & animal cells. The beta-thymosins are a family of proteins. 16 known versions are in this class of compounds. Thymosin Beta 4, otherwise known as TB-4 is naturally found in human blood platelets. It is also found in white blood cells, in the thymus gland as well as the spleen. It is believed to play a large role in cell survival, as well as in the repair and regeneration of damaged tissue.
T4 is an actin-regulating peptide. Actin is a vital component of cell structure & movement of the body. Actin is up to 10% of the total proteins present in the cells, making it a major player in the genetic infrastructure of a cell. T4 plays an important function in the body whereby it protects & restores damaged tissue.
TB-500 has been shown to produce proteins & growth factors that promote rapid wound healing, increased muscle growth, with large increases in endurance & strength as well as potent anti-aging & anti-scarring properties.
TB-4 has shown great promise healing patients with pressure and venous ulcers. It has also displayed healing properties for patients with corneal wounds and heart attacks.