Archive for IGF

Why it’s worth combining IGF-1 and Growth Hormone

igf-1

Bodybuilding peptide vial

Why it’s worth combining IGF-1 and Growth Hormone

 

The first argument that Janssen comes up with is that IGF-1 remains active for longer in the body if you inject it in combination with growth hormone. This is because IGF-1 is active for longer if it is attached to the binding protein IGFBP3.
If you inject IGF-1 on its own, the production of this binding protein goes down. But if you inject growth hormone and IGF-1 together, the concentration of this binding protein increases. That might mean that you would have to inject less frequently, as IGF-1 breaks down quickly in the body.

A second argument is that growth hormone makes the cells ‘ignore’ insulin. As a result, blood sugar levels rise, as does the insulin level. In the long run this might not be so beneficial to health, and it would inhibit muscle growth. If you use IGF-1 together with growth hormone, then the muscle cells become more sensitive to insulin. And that would mean more muscle protein build-up.

The advantage of combining IGF-1 and GH

 

is also a potential disadvantage, according to Janssen. On a molecular level the same processes involved in muscle growth are also found in cancer cells and tumors. The combination of both hormones might therefore give any tumors a growth stimulus. The same applies to other side effects such as undesirable growth of the jawbone, headache and trapped nerves in the hands.

In the final section of the article, the endocrinologist stresses that there have been very few studies on the effect of combined administration of GH and IGF-1, and that his article is mainly theoretical. “Determination of whether co-administration of GH and IGF-I is indeed superior to GH alone or IGF-I alone awaits further study”, concludes Janssen.

source: http://www.ergo-log.com/ghigf1.html

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Insulin-like Growth Factor LR3 (IGF-1)

Insulin-like Growth Factor LR3 (IGF-1)

Insulin-like Growth Factor (Long-R3 IGF-1), an 83 amino acid analog of IGF-1 is a highly anabolic hormone released primarily in the liver with the stimulus of growth hormone (HGH).
IGF-1 is the most potent growth factor found in the body and causes muscle cell hyperplasia.

IGF-1 LR3 Dosage(Long R3 IGF-1)

Light: 25 mcg
Common: 50 mcg
Large: 100 mcg
IGF-1 is administered for one month, give or take a week.

Long r3 IGF-1 storage

Freeze dried (lyophilized) IGF-1 (in powder state) should be stored in the freezer (-18 degrees Celsius).

What you will need to reconstitute Long r3 IGF-1

1000mcg of lyophilized (freeze dried) Long R3 IGF-1
2 mls of 0.6% Acetic Acid (AA)
30ml Sodium Chloride (NaCL) as buffer

Dilute the IGF-1 peptide with 2mls of Acetic Acid (.6%). Assuming (*DO NOT ASSUME*) Acetic Acid (AA) will yield the correct pH balance of your research peptide.
Note: This creates a concentration of 500mcg/ml. So each 1/10 of a ML is 50mcg’s.

Draw the desired amount of IGF in to a syringe. Desired amount should be the approx. dosage wanted.
Example- 2mls AA used to reconstitute IGF-1 1mg vial means 5 units on a U100 insulin syringe would equal 25mcg IGF-1 LR3
Pre-load your syringes at 5iu (25mcg IGF-1). Divide your IGF-1 into 40 syringes for storage in the freezer.
Thaw prior to administration. Draw from your NaCL after thawed to buffer (.5ml is enough).

Unknown whether injecting IGF-1 to increase muscle growth is efficacious. Many believe in the value of this powerful growth factor.
It is possible to go into hypoglycemia from IGF-1 supplementation. Effect is dose dependent.

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