MGF – MECHANO GROWTH FACTOR
MGF (mechano growth factor) has been used by bodybuilders and athletes for a few years already. After resistance exercise, IGF-1 is released within the muscle. Specifically, at this time, immediately following the mechanical use of a muscle, the IGF-I gene is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. It does so both by activating muscle stem cells and satellite cells, but also via various other anabolic processes. (1) It differs from “regular” IGF-1 mainly due to it’s C-Terminal sequence.
MECHANO GROWTH FACTOR Background
It was first discovered in the muscle by Goldspink, et al. In human muscle, a 49-base insert changes the reading frame in mechano growth factor (MGF) as compared to IGF-1.
What does MGF do?
When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary anabolic mechanism by which the body produces new muscle. MGF is available as an injectable peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.
From Studies done on MGF
In a rodent study, a single intramuscular injection into muscle resulted in a 25% increase in mean muscle fibre cross section area within three weeks. Using a similar protocol, liver-derived IGF-1 took four months to produce a 15% increase.
It would also appear that with regards to age, the young have a better ability to respond to MGF (4), and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.
What is Mechano Growth Factor?
Mechano Growth Factor is produced by our muscles after a strenuous workout or after our muscles have been overloaded and have broken down. Perhaps better known in the exercise world as when muscles are torn down by a lot of cardio and especially heavy weight lifting. When the muscles are injured it is our body’s natural reaction to rebuild and repair the torn muscles or damaged tissue. This is when our body releases Mechano Growth Factor, also a component of IGF-1. Mechano Growth Factor is released in pulses after muscle tissue is shredded down. The Growth Factor then helps the tissues stem cells repair themselves and the muscle begins to rebuild itself.
There are different types of Mechano Growth Factor. As our body gets older and certain organs or skeletal components start to loose vibrant proteins, Mechano Growth Factor can kick in to help repair these areas as well. Areas such as our liver, pancreas, kidneys and our smaller skeletal adjoining muscles. Of course these different types of Mechano Growth Factors, differ in their synthesis but ultimately they do the same thing. They help rebuild torn, broken or damaged tissues.
Now, if you are an athletic enthusiast or body builder then Mechano Growth Factor is incredibly important for your overall performance and success because your muscles need to rebuild quickly and advantageously. The down side to Human Growth Factor is that it has a short processing life span and does not stay within the muscle for a long period of time. This is why supplementation is needed. But even with supplementation, Human Growth Factor, by itself, does not stay in the muscles long to aid in repair. So, an FDA approved, polyethylene glycol, also known as PEG, a protein molecule, has been attached to Human Growth Factor supplements in order for the restoring component to subside in the muscles for a longer period of time. By linking this protein along with Human Growth Factor, athletes and body builders can reap the greatest benefits from Human Growth Factor through injection supplementation. By utilizing the polyethylene glycol protein, the Human Growth Factor stays in the body and repairs muscle tissues for a longer period of time instead of just minutes.
So, whether you are aware or not, that your body is producing Human Growth Factor to repair your muscles after a hard weight lifting session, it is still important to supplement with injectable Human Growth Factor to get the most out of your work outs and training. To obtain the best results, supplementation is a must for muscle repair and gain, and now that a protein has been added to Human Growth Factor, your muscles and athletic achievement can reach its full potential.