Archive for PEG-MGF

MGF + IGFr3 bodybuilding peptide cycle

MGF + IGFr3 bodybuilding peptide cycle

Mechano Growth Factor (MGF). We know things like IGF creates new muscle cells and helps drop body fat and MGF helps facilitate this muscle growth and fat loss.

Most of us are familiar with the peptides Insulin-Like Growth Factor (IGF) and In Mechano Growth Factor (MGF). We know things like IGF creates new muscle cells the beginning:

When IGF first made its way onto the bodybuilding scene most people were injecting it every day and noticed that after somewhere around 30 days the effects of IGF wore off. This was blamed on receptor “down-regulation” or “desensitization”. To combat this people started a 5-on 2-off rotation and then went to a post workout only rotation which extended the time on IGF an additional 10-20 days. But the problem with the lack of “receptor response” was still present.

Then MGF came onto the scene. MGF was suppose to be the next best thing in bodybuilding. It was suppose to be more anabolic than AAS and better suited for building new muscle than IGF, the problem was that it wasn’t. Because of its instability it was quickly broken down once injected into the body, to prevent this Peg-MGF was created. This new MGF was now able to survive in the body from anywhere in the 1-3 days. Combining this new peptide discovery with IGF was suppose to be able to make all of us the next Mr. Olympia. But what happened? Why do we not see a flood of new pros?

What happens when both MGF and IGF are used together:

In theory these two peptides should cause some great results, the problem is they do not work together very well unless your timing is spot on (I will go into greater detail later). In short stem cells in the presence of MGF will cause the cells to split and multiply. When the cells are multiplying they cannot form new tissue and the effects of IGF are completely blocked. So the two together are not very compatible.

Then why not just use IGF? Well most do use IGF only and get great results, but there is that pesky business of receptor “down-regulation” or “desensitization” and you have to end a cycle of IGF after 30-50 days and there is no way to prevent it… or is there?

The science behind using MGF and IGF:

In a natural system (Our Body) we have peaks and dips with MGF and IGF levels. The reasons for these peaks and dips are to create the ideal amount of cells to repair and create new tissue. After strenuous exercise the levels of MGF in the body (more specifically in the muscle just trained) increase dramatically and there is a dramatic decrease of IGF levels. The reason for this is because MGF causes stem cells to proliferate (split and multiply). This process ensures that there are enough cells available to make repairs and to create new tissue in order for the tissue to function efficiently and properly (in this case skeletal muscle tissue). As mentioned above in the presence of MGF there is no need for IGF because it is rendered useless and cannot activate the stem cells, so this explains the bodies response to decrease IGF levels.

In 12-36 hours MGF levels begin to drop and there is a direct correlation in the rise of IGF levels within the body. Stem cells have proliferated and now the IGF will bind to the proper receptors and cause differentiation (force the stem cells to form into a specific cell for a specific tissue type). This process repeats every time you exercise and keeps the natural system in an efficient state.

When flooding the body with these artificial bodybuilding peptides a person will change this natural system dramatically. A person using MGF only is causing stem cell proliferation while at the same time preventing IGF to perform its duties of creating new tissue from those newly created stem cells. A person using IGF only is depleting the supply of stem cells at a rate much faster than the body can keep up, leading to a depletion of available stem cells and not receptor “down-regulation” or “desensitization.”

This sounds like a lose-lose situation. You are throwing off your body’s final tuned muscle repairing mechanism, depleting valuable stem cells or creating too many stem cells for your body to deal with. Why bother?

The climax:

The reason why we bother is because we want to reach or goals. We want to be the biggest bodybuilder, the best powerlifter or whatever it is that we are training so hard for. These Bodybuilding peptides are a great addition to our arsenal, but learning to use them properly is the key to utilizing their benefits.

The key is retraining the way we think about MGF and IGF. We have to understand that we are dealing with the creation and depletion of stem cells that are going to be responsible for our muscular growth. Our bodies do not have a constant supply of these stem cells and our bodies will not naturally utilize all of the stem cells it has created. Since we are trying to artificially manipulate the amount and utilization of these stem cells we have to look at this is a different manner.

While we may never get the exogenous MGF and IGF levels just right so that we may counteract the depletion of the stem cells we can adjust our protocols in a way that will increase the amount of time a person can use and respond to both peptides.

The Conclusion Part 1, MGF:

We know that the PegMGF will stay in the body for several days and we know that while in the presence of MGF stem cells will proliferate and the use of IGF is futile. We also know that MGF without the peg is of little to no help because of how quickly exogenous MGF is broken down within the body. So what are the options?

Well both can be of use!  Peg-MGF can be of great use as long as the individual using the peptide in conjuction with IGF understands that the two peptides must be injected in a manner that falls outside of the current way of thinking. And MGF without the Peg addition can also be utilized as long as you don’t mind being a pin cushion.

The key with MGF is to learn to either follow your bodies natural peaks and dips of MGF levels and force proliferation on a larger scale with MGF, or to force a longer period of cell proliferation with the use of PegMGF. The key is you have to have stem cells in order to create new muscle tissue.

The Conclusion Part 2, IGF:

Now that we have hit the MGF part of the cycle, now we move into the part of the cycle that utilizes the stem cells. Again we want to either follow the body’s natural peaks and dips of IGF levels or we are going to want to cause a prolonged forced differentiation phase. The latter of the two options is simply following standard protocol of everyday injections or 5-on 2-off. The other is all about timing. We know that MGF levels peak in the body after strenuous exercise, so why would you want to inject a substance that is useless in the presence of MGF right when MGF levels are at their highest? The answer is you don’t! You will want to wait and inject the IGF 24hrs after the exercise. This will give ample time for the MGF peak to start to dip and can closely mimic the natural rise in IGF levels. This will allow for a person to use a more efficient dose since the timing of the IGF will correspond closely to the dip in MGF levels resulting in greater utilization of the exogenous IGF.

The Peg-mgf, igf-1r3 cycles:

There are a few cycles I would recommend.

The first being IGF only. It works, maybe not the most efficient plan out there but it does work none-the-less.

The second would be the Peg-MGF/IGF combination. This is not the most efficient methos but should significantly increase the amount of time one can be on an MGF/IGF cycle and still see positive results. (This may have to be altered according to your training schedule)

Sunday – Off Training – Mid-day Peg-MGF 200-300mcg
Monday – Training (Afternoon)
Tuesday – Off Training – Afternoon IGF 40-80mcg
Wednesday – Training (Afternoon)
Thursday – Off Training – Afternoon IGF 40-80mcg
Friday – Training (Afternoon)
Saturday – Off Training – Afternoon IGF Injection 40-80mcg

The addition of the Peg-MGF will cause an increase in amount and duration of stem cell proliferation and should subside about the period of the first IGF injection. While this will not keep stem cell levels stable it should prevent the drastic decrease in stem cell numbers seen with IGF only cycles and should significantly increase cycle length.

The third would be the use of regular MGF plus the addition of IGF and woulld closely mimic the natural system.

Sunday – Off Training
Monday – Training (afternoon) – 1hr PWO MGF 50mcg in muscles trained
Tuesday – Off Training – Afternoon IGF 40-80mcg
Wednesday – Training (Afternoon) – 1hr PWO MGF 50mcg in muscles trained
Thursday – Off Training – Afternoon IGF 40-80mcg
Friday – Training (Afternoon) – 1hr PWO MGF 50mcg in muscles trained
Saturday – Off Training – Afternoon IGF 40-80mcg

This protocol should closely mimic natural peaks and dips in MGF and IGF within the specific muscles being trained. While regular MGF is short lived in the body the addition on the regular MGF 1 hour post workout should cause an increase in cell proliferation beyond the natural system’s ability and should create a larger pool of stem cells for the utilization of IGF therapy.

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Bodybuilding PEGylated MGF

Bodybuilding PEGylated MGF

I was originally going to wait until the end of my trail with PEG-MGF (herein further referred to as pmgf) before posting my results and information, but my PM box has been flooded with information requests, so instead of waiting, I am going to post a blog that will be updated weekly.

Let’s start with an explanation of Mechano Growth Factor (MGF) and what it does. The C-terminal peptide of mechano-growth factor (MGF), an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), was found to function independently from the rest of the molecule. At any rate, IGF-I exists in multiple isoforms (tissue-specific proteins of functional and structural similarity). One isoform, which differs from the systemic or liver type, happens to be particularly sensitive to mechanical signals such as the gamut of exercise overload. This important isoform, called mechano-growth factor (MGF), is a local splice variant of IGF-I produced by damaged or loaded skeletal muscle.

The physiological function of a recently cloned splice variant of insulin-like growth factor-I (IGF-I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.
Yang SY, Goldspink G. FEBS Lett. 2002 Jul 3;522(1-3):156-60.

So what is pegylation? In simple terms it is the process of attaching one or more chains of a substance called polyethylene glycol (PEG) to a protein molecule such as IGF or in this case MGF. Since the body does not react to PEG, it helps provide a protective barrier around an attached protein so it can survive in the body longer. This is highly beneficial for systemic products that must survive repeated attacks by enzymatic exposure. PEG is an inert non-toxic substance that can provide protection to amine groups since they are flexible and allow attachment by bioengineered processes to the receptor bearing cell.

Finally a quick explanation of polyethylene glycol; Any of a family of high molecular weight compounds that can be liquid or waxlike in consistency and are soluble in water and in many organic solvents.

Alright, now that you have sifted through my semi-scientific yet easy to read explanation of pmeg, let’s get to the main point of the article, my experience. First off, I was asked to test this new product. They supplied me the product and requested I use it at 200mcg, two times per week. I agreed on the condition that no matter what the results, good or bad, my review would be brutally honest. If they were looking for someone to just promote their product, I was not their guy. They agreed unconditionally and shipped the product out immediately.

Let me preface what follows below are my results but they will not be typical for most users. Having already accumulated up to 270lbs of mass over the years, my muscle memory is outstanding and I am easily able to rebound when using products. At this time, I have been off cycle for 2 months, using only 500mg test enanthate per week as HRT. This is my first time off cycle in over 8 years. I was also using 2iu gh per day but stopped using it at the request of IBE. My diet and training did not change, I was trying to create as stable an environment to test this product as would allow.

I started at a current bodyweight of 227lbs with my bodyfat measured at 14.8% and 55% water balance. I have some sophisticated test equipment at home so I can be sure my stats and my ability to track results are fairly accurate. I have been using this product for 4 weeks now, still having 4 weeks to go. After that, I will cycle off for a few weeks and then resume with a new test trial using mgf, igf, slin, and gh with small amount of anabolics in a very androgen rich environment. I will utilize many small injections with specific timing to maximize my results, but that is for another article.

My first week of use was a tough one for me, I had to come off the gh and immediately notice a decrease in lean mass, as well as longer recovery between workouts. This subsided very quickly though with the introduction of pmeg. My current workout schedule is on Tues, Thurs, and Friday. I decided to use the pmeg on Tues and Thurs, my two biggest bodypart workout days. I was instructed by IBE to test it sub-q since it is systemic anyway and the injection method was somewhat irrelevant. On my next trial, I will be using it IM in a specific sequence with other peptides.

My first week of use, my weight stabilized as did my body fat percentage. I was quickly able to stop my wasting from coming off cycle and gh, and reintroduce beneficial cell growth potential. The changes from my first to second week were dramatic to say the least. Not only was I getting skin tight pumps, my vascularity was up, but the scale was most telling off all. I went from 227lbs to 232lbs by the end of the second week. At this time my water balance and body fat were still the same. The third week was another major change, even more so than the first two weeks. My weight jumped up to 235lbs but most incredible of all was the fat loss. Let me remind you that I did not make any diet changes; I just added this product in mostly as a pct product while coming off cycle. So what impressed my most was my body fat dropping from 14.8% to 12.9%. I just finished my 4th week yesterday so I jumped back on the scale to see what changes were in store for me now!

This was the best week yet. Before you get all freaked out, please remember that I just came off an 8 year cycle, my body fat jumped up from the estrogen increase and I was gaining back weight I had lost from not bulking anymore. Ok, with that out of the way again, here is week 4: Weight backed off a bit to 234lbs, but my body fat melted down to 10.9%, a drop of almost 4% since starting this just 4 weeks ago. The other awesome gain was my cellular water balance was up to 58% which is an indication of intra-cellular water balance for overall health, condition, and prevention from muscle and joint tissue damage.
PegMGF Journal by “Almost Pro”
My Pegylated Mechano Growth Factor trial
By Gavin Kane

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