Archive for TB-500

What is Thymosin Beta 4 (TB 500)?

Thymosin Beta 4 was first found in the thymus gland. Thymosin is typically found in both skeletal and smooth muscle. Thymosin Beta 4 is upregulated when the body experiences tissue damage. When a trauma injury occurs, the body releases Thymosin Beta 4 to heal from the trauma. Thymosin prevents adhesions from occurring, minimising scar tissue.

Benefits of Thymosin Beta 4 (TB-500)
Immune Enhancer
Rapid Injury Repair and Recovery
Reduces Inflammation
Tissue repair and regeneration
Increases Muscle Growth
Improves Muscle Tone
Increases Strength and Endurance
Promotes Hair Growth
Relaxed muscle spasm
Increases the exchange of substance between cells
Stretches connective tissue
Minimises Scar Tissue Formation
Helps Maintain Flexibility
Keratinocyte Migration
Collagen Deposition
Promotes New Blood Cell Growth
Promotes Cell Differentiation
Prevents formations of adhesions and fibrous bands in muscles, tendons and ligaments
Thymosin beta 4 will now be tested as a potential treatment for HIV, AIDS & Influenza virus

Mechanism of Action for Thymosin Beta 4 (TB 500):

Thymosin Beta 4 is a hormone secreted from the thymus, in which the primary function is to stimulate the production of T-cells. T cells are a very important part of the immune system.
thymosineffectsThymosin also contributes to the development of B cells into plasma cells to produce antibodies.

Thymosin Beta four is a first-in-class naturally occurring peptide present in virtually all human & animal cells. The beta-thymosins are a family of proteins. 16 known versions are in this class of compounds. Thymosin Beta 4, otherwise known as TB-4 is naturally found in human blood platelets. It is also found in white blood cells, in the thymus gland as well as the spleen. It is believed to play a large role in cell survival, as well as in the repair and regeneration of damaged tissue.

T4 is an actin-regulating peptide. Actin is a vital component of cell structure & movement of the body. Actin is up to 10% of the total proteins present in the cells, making it a major player in the genetic infrastructure of a cell. T4 plays an important function in the body whereby it protects & restores damaged tissue.

TB-500 has been shown to produce proteins & growth factors that promote rapid wound healing, increased muscle growth, with large increases in endurance & strength as well as potent anti-aging & anti-scarring properties.

TB-4 has shown great promise healing patients with pressure and venous ulcers. It has also displayed healing properties for patients with corneal wounds and heart attacks.

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How to use TB-500 (Thymosin beta 4) for healing purposes

HOW TO USE TB-500 Thymosin beta 4 for healing benefits

Research has shown that the best results are achieved when using sterile saline solution (Sodium Chloride Injection BP 0.9%) to mix TB-500 (thymosin beta4).

Only prepare the vials that will be used immediately. If using doses that are lower than the recommended dose, prepared vials must be stored in the fridge and be used within 8 days.

Vial preparation:
Remove the plastic protective cap of the sealed vial containing the powder of peptides.

Insert the filled syringe of 2ml of sodium chloride solution into the rubber top of the vial and release the 2ml of sodium chloride into the vial.

Remove the syringe and gently rotate the vial until the powder is completely dissolved.

Ensure that the solution is well mixed with all powder thoroughly dissolved for maximum safety and effectiveness.

A Subcutaneous (S/C) inj.

Research studies have further shown that one (2ml. vial) Sub-Q Inj. each week for six consecutive weeks provides the best results.  There after, use only one (2ml. vial) per month.  It’s best to give the Sub-Q Inj. 6 days before intense work outs. Therefore for best results, one vial per Sub-Q injection per week for 6 consecutive weeks, then 1 vial per month (the glass vial is 2ml, with 10mg TB-500 per vial), so it is 10mg/2ml).

No known contraindication with tb4 peptide products, however tb500 has not been thoroughly tested to know its full effects.
The product should not be used if the subject is pregnant or breast feeding.

TB500 Storage:
Store the product at room temperature in a non humid environment. An opened vile can be kept for up to 8 days in refrigerated storage.


What is TB-500?
TB-500 is a synthetic version of the naturally occurring peptide present in virtually all human and animal cells, Thymosin Beta 4 (TB-500). It is a first-in-class drug candidate that promotes the following*:

•  Endothelial (blood vessels) cell differentiation
•  Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues
•  Keratinocyte migration
•  Collagen deposition; and
•  Decreases inflammation.
One of TB500 key mechanisms of action is its ability to regulate the cell-building protein, Actin, a vital component of cell structure and movement. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins which therefore plays a major role in the genetic makeup of the cell.

This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. Thymosin beta-4 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule.

Tß4 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells.

An additional key factor of TB500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.

Research confirms that TB500 is a potent, naturally occurring wound repair factor with anti-inflammatory properties. TB-500 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues.

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