delta sleep inducing peptide

delta sleep inducing peptide

Stimulates release of luteinizing hormone (LH)

In males, LH acts upon the Leydig cells of the testis and is regulated by GnRH. The Leydig cells produce testosterone (T) under the control of LH, which regulates the expression of the enzyme 17-β hydroxysteroid dehydrogenase that is used to convert androstenedione, the hormone produced by the gonads, to testosterone, an androgen that exerts both endocrine activity and intratesticular activity on spermatogenesis.

Stimulates release of Growth-hormone-releasing hormone secretion

GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophyseal portal system to the anterior pituitary gland, where it stimulates growth hormone (GH) secretion by stimulating the growth hormone-releasing hormone receptor. GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH. In addition, GHRH also promotes slow-wave sleep directly. Growth hormone is required for normal postnatal growth, bone growth, regulatory effects on protein, carbohydrate, and lipid metabolism

Stimulates release of somatotrophin secretion

Growth hormone (GH or HGH), also known as somatotropin or somatropin, is a peptide hormone that stimulates growth, cell reproduction and regeneration in humans. some doctors have started to prescribe growth hormone in GH-deficient older patients (but not on healthy people) to increase vitality
In its role as an anabolic agent, HGH has been used by competitors in sports at least since 1982, and it has been banned by the IOC and NCAA

growth hormone has many other effects on the body:

•Increases calcium retention, and strengthens and increases the mineralization of bone
•Increases muscle mass through sarcomere hypertrophy
•Promotes lipolysis
•Increases protein synthesis
•Stimulates the growth of all internal organs excluding the brain
•Plays a role in homeostasis
•Reduces liver uptake of glucose
•Promotes gluconeogenesis in the liver
•Contributes to the maintenance and function of pancreatic islets
•Stimulates the immune system
•Increases deiodination of T4 to T3

Inhibits somatostatin secretion

Somatostatin is a hormone produced by the hypothalamus and some other tissues such as the pancreas and the gastrointestinal tract. It inhibits the release of growth hormone from the anterior pituitary, and insulin and glucagon from the pancreas.

Somatostatin also decreases the release of most gastrointestinal hormones and reduces gastric acid and pancreatic secretion. It can reduce abdominal blood flow therefore somatostatin analogs can be used to reduce bleeding from esophageal varices.

Somatostatin was first discovered in hypothalamic extracts and identified as a hormone that inhibited secretion of growth hormone. Subsequently, somatostatin was found to be secreted by a broad range of tissues, including pancreas, intestinal tract and regions of the central nervous system outside the hypothalamus.

Roles in physiological processes:

•Can act as a stress limiting factor.
•May have a direct or indirect effect on body temperature and alleviating hypothermia.
•Can normalize blood pressure and myocardial contraction.
•It has been shown to enhance the efficiency of oxidative phosphorylation in rat mitochondria in vitro, suggesting it may have antioxidant effects.

There is also conflicting evidence as to its involvement in sleep patterns. Some studies suggest a link between DSIP and slow-wave sleep (SWS) promotion. It has been found to have anticarcinogenic properties. In a study on mice, injecting a preparation of DSIP over the mice’s lifetime decreased total spontaneous tumor incidence 2.6-fold. The same study found it to also have geroprotective effects: it slowed down the age-related switching-off of oestrous function; it decreased by 22.6% the frequency of chromosome aberrations in bone marrow cells and it increased by 24.1% maximum life span in comparison with the control group.

Levels of DSIP may be significant in patients diagnosed with major depressive disorder (MDD). In several studies, levels of DSIP in the plasma and cerebrospinal fluid are significantly deviated from the norm in patients with MDD, though there are contradictions as to whether levels are higher or lower than healthy control patients. Studies have shown that administration of DSIP can alleviate narcolepsy and normalize disturbed sleeping patterns.

Taken from various articles and studies throughout the net

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