The smallest unit of Protein is an amino acid. Amino acids can be double bonded, triple bonded, and a chain of amino acids. Peptides are a short chain of amino acids linked by peptide bonds. Peptides have acute affect on skin, metabolism, IGF levels, and protein synthesis. For sakes of keeping this discussion to HGH increasing peptides I will not cover the other peptides that are less relevant, and don’t have enough studies to base a solid case on the factors that increase IGF levels.
There are two peptide types that are used to increase Human Growth Hormone Levels and one of them is called GHRH, or Growth Hormone Releasing Hormone. The other type of peptide is called GHRP, or Growth Hormone Releasing Hexapeptide. We are going to summarize these peptides in the most basic terms to avoid confusing people who are interested in using them. There are about 6 peptides that we can group in these two categories, and we will discuss which one may be right for your goals.
Peptide CJC-1295 and IGF-MOD 1-29 are two of the most used GHRH. CJC-1295 has a 7-8 day half life, and IGF-MOD 1-29 has a 30 minute half life. Their actions are almost the same and their preference may be based on frequency of injections, or factual information that may benefits its usage. We have to understand a few things about Natural HGH, and that Natural HGH functions in a pulsatile manner. The pulses communicate information to the cells, in which that information in within the cells mediates events such as protein synthesis, metabolism,collagen synthesis, and IGF levels. CJC-1295 which is a GHRH does not increase the pulses but the HGH base levels. GHRH while effective on their own may lessen their benefits in the presence of higher levels of Somatostatin. In a way what actually matters is the free GH levels if you want to look at things with a more logical perspective. There are some other factors to think about. The moment that levels of the HGH Inhibitor known as Somatostatin increase, HGH cannot be released. So understanding the role that Somatostatin has on Human Growth Hormone is very important. With that said, CJC-1295 signals the release of HGH once the levels of Somatostatin decrease. In terms of understanding HGH, our body doesn’t always release HGH but the most predictable times are normally during sleep (2-3 hours), post work-out, and early in the morning.
The other GHRH is IGF-MOD 1-29. It has a 30 minute half life, and for that reason it has to be dosed 3 times a day minimum to get the best results. A couple of things to keep in mind with IGF-MOD 1-29 is that you must follow a proper dietary protocol. Carbohydrates blunt the release of HGH, and for that reason waiting 30 minutes to 60 minutes after dosing is a must. And also waiting 2 hours after your eat prior to dosing is important. People will look at the half life benefit of CJC-1295 and may think that is superior but they have to look at a couple of facts. The constant low release of HGH (sometimes refer to as bleed) will have an effect on the Somatotrophs, or the growth hormone releasing cells. The effect will be a negative one and is mainly because the Somatotrophs won’t communicate properly due to the cells being overworked which will cause the HGH pulses to be less effective when created. Keep in mind that GHRH doesn’t create pulses but it increases them when there are pulses present. With that said, IGF-MOD 1-29 is preferable for body composition purposes because it responds better by our body, and is more effective over a long period of time. If people are set in using CJC-1295 then they can experiment at least by discontinuing its usage for a period of time.
Dosing on specific peptides alone have lesser benefits, and dosing GHRH peptides alone still give you good benefits but they give you an even better synergistic benefit when you dose them with any of the types of GHRP peptides. We can discuss what GHRP does but is most useful role in my opinion is suppressing the actions of Somatostatin (HGH inhibitor). GHRH can cause a pulse alone but if Somatostatin is present then it won’t be effective; however GHRP creates a pulse but this pulse is not a very effective alone. There are 4 types of GHRP Peptides found and each of them have different actions. The most common GHRP used is GHRP-6, and is one of the most potent ones. One of the side effects of GHRP-6 is that it increases appetite which is something people will find useful. Then there is Hexarelin, which is the most potent GHRP, and doesn’t have the hunger side effect that GHRP-6 has. The two other GHRP types are Ipamorelin, and GHRP-2 which are the less potent ones. GHRP-6 and Hexarelin are the most potent ones but the ones that are more prone to desensitization during longer period of times, and higher dosages. The good thing about the GHRP-6 and Hexarelin peptides is that there is no need to dose beyond 100 mcg to 150 mcg since these are the doses where saturation is reached. The other peptides, Ipamorelin and GHRP-2 have shown no desensitization when taken on longer periods,and at higher dosages. They are actually more favorable to use over long periods of times, and at higher dosages.
Since we learned quite a lot about how these peptides work we can actually come to a really good conclusion in terms of increasing your own HGH natural levels, if you combine both GHRH and GHRP then not only is a pulse going to be created but the pulses will also increase vastly enough to affect the actions or benefits of higher HGH levels such as an increase in lean mass, decrease in fat loss, metabolism, elevated protein synthesis, collagen synthesis, increase in bone density, improved sleep, recovery, repair, and increases in IGF levels. I have listed a chart for the convenience of others. I don’t encourage the use of peptides below the age of 21. Follow at your own risk for you deem yourself fully responsible for your own use of peptides. I encourage people to do their own research and come to their own conclusions based on the behavior of peptides from a molecular level.