Tag Archive for ghrp-2

GHRP-2

GHRP-2

CAS:
Formula: C45H55N9O6
Molecular weight: 817.9
Peptide purity: > 98.0%
Appearance: White powder
Related substance: Total Impurities(%) = 2.0%
Acetate content: = 15.0%
Bacterial Endotoxins: =5 IU/mg
Chain:D-Ala-D-ß-Nal-Ala-Trp-D-Phe-Lys-NH2

Uses

Improve sex drive and desire by stimulation of hypothalamus
Reduces belly fat through lipolysis
Increases energy and vitality
Improves skin elasticity, ridding wrinkles
Increases endurance
Accelerates healing from wounds or surgery
Strengthens the heart
Enhances the immune system
Increases IGF-1 production, by as much as 50% in first week
Improves sleep quality
Increases calcium retention, strengthens and increases the mineralization of bone, bone density
Increases protein synthesis,
Improves eyesight and vision
Reduces liver uptake of glucose, an effect that opposes that of insulin
Promotes liver glucogenesis
Contributes to maintenance and function of pancreatic islets

GHRP2 growth hormone releasing peptide therapy is considered one of a few medical means of reversing the effects of aging in adults deficient in growth hormone. This is because of the benefits resulting from the increased stimulation and secretion of human growth hormone by the pituitary gland hypothalamus,axis HPA.

GHRP-2 also known as KP 102 is a commercially synthesized, growth hormone releasing hexapeptide. It is a super-analog of the GHRP-6 which is capable of potent stimulatory effect on growth hormone (GH) secretion with slight stimulator effect in PRL, ACTH and levels of cortisol).

Growth Hormone Releasing Peptide 2(GHRP-2) substantially stimulates the pituitary gland’s increased natural production of the body’s own endogenous human growth hormone (hgH). This therapy consists of daily periodic sub-lingual dosing. Growth Hormone releasing peptide 2, GHRP-2 has shown on it’s own to robustly increase IGF-1 levels, and even greater results occurred when used with Growth Hormone Releasing Hormone (GHRH) to which also stimulates the pituitary gland to produce increased natural secretion of human growth hormone. This also boosts the hypothalamus function as well.

GHRP-2 is a true hgH secretagogue. It stimulates the body’s own secretion of hgH as explained herein. Human Growth hormone has been shown in studies to promote lean body mass and reduce adiposity (fat). GHRP2 has demonstrated that it is very effective at stimulating GH production in research test subjects. It has a short half life with peak concentrations occurring around 15 minutes and not longer than 60 minutes after administration.

Growth hormone releasing peptide is a commercially synthesized, non-natural super-analog of the GHRP-6 which is capable of potent stimulatory effect on growth hormone (GH) secretion with slight stimulator effect in PRL, ACTH and levels of cortisol (Arvat et al. 1997). It is also a synthetic agonist of ghreline that is binding with the growth hormone (GH) secretagogue receptor. GHRP-2 has been shown to affect and induce growth hormone secretion. The response of natural physiologic system includes increase in levels of calcium ion influx alongside with increased release of growth hormones in response to this peptide (Wu et al. 1994). Its chemical structure and other chemical properties are described below:

Furthermore, dose-dependent investigations have proven that this analog is similar in terms of potency with GRF and was even tenfold more potent than earlier generations of GH-releasing secretors such as GHRP-6 and GHRP-1 (Wu et al. 1994). Because of such effects, this hormone has been used for the treatment of different monkey deficiencies and catabolic states. Studies of Laferre et al. (2005) have shown that GHRP-2 acts like ghrelin which induces food intake in monkeys and also stimulates GH secretion. This has been demonstrated when GH levels rose significantly during GHRP-2 infusion (AUC 5550 ± 1090 µg/L/240 min vs. 412 ± 161 µg/L/240 min, p = 0.003). Also, GHRP-2 has shown to be inducing secretion of cAMP in cells in a manner similar to that of GRF. GHRP-2 supplication has also acted as an anti-inflammatory effect in arthritic rats and seems to be mediated by ghrelin receptors directly on immune cells (Granado et al. 2004). However, it is important to note that the level of results with the action of GHRP-2 differs accordingly with species specifically in the response of the pituitary somatotrophs probably because of differences in the subtypes of GHRP receptors (Wu et al. 1996). Its action however in the physiologic system is blocked by GRF receptor antagonist which acts through a different receptor to that employed by earlier GHRPs.

Share with your friendsEmail this to someoneTweet about this on TwitterShare on Google+Share on FacebookPin on PinterestDigg thisShare on StumbleUponShare on TumblrShare on Reddit

GHRP Bodybuilding Peptides Dosage Instructions

GHRP Bodybuilding Peptides Dosage Instructions

The information below relates to using GHRP peptides (GHRP-6, GHRP-2 or Ipamorelin) as standalone products. For information about which other peptides they combine well with, please visit the Peptide Combinations guide.

Recommended Dosages
Before using these products, please ensure you have viewed the videos demonstrating how to correctly mix and inject GHRP peptides.

GHRP-6 or GHRP-2
Dose per injection: 200mcg
Injections per vial: 25 x 200mcg dosages
Amount to Inject: If you have used 1ml of water for mixing then a 200mcg dosage = 0.04ml (or 4 units on Insulin Syringe). If you have used 2ml of water for mixing then 200mcg = 0.08ml (or 8 units) and if you have used 3ml of water for mixing, then 200mcg = 0.12ml (or 12 units).

Ipamorelin
Dose per injection: 200mcg
Injections per vial: 10 x 200mcg dosages
Amount to Inject: If you have used 1ml of water for mixing then a 200mcg dosage = 0.10ml (or 10 units on Insulin Syringe). If you have used 2ml of water for mixing then 200mcg = 0.20ml (or 20 units) and if you have used 3ml of water for mixing, then 200mcg = 0.30ml (or 30 units).

Injection Frequency
The same injection frequency applies for any of the three GHRP peptides (GHRP-6, GHRP-2 or Ipamorelin). Optimal times are first thing in the morning, pre or post workout and at night before bed.

Beginners: 1 time per day
Intermediate: 2 times per day
Advanced: 3 times per day

Diet Restrictions
Pre-injection: Fat and carbohydrates both blunt the release of Growth Hormone (which is the whole purpose of taking GHRP), therefore you should avoid any meals/beverages high in fat for 2-3 hours before your injection. The only exception to this rule is if you are combining your GHRP peptide with a CJC-1295 peptide, in which case you only need to wait 1 hour after eating before your injection as the combination has been proven to overcome the negative impact by food on GH release.

Post-injection: GHRP products take approximately 5-30 minutes to exert their effect on GH release in the body, therefore you should wait for at least 30 minutes after your injection before consuming any food or beverages (besides water) as they may diminish the effectiveness of your injection. After 30 minutes have passed, those looking to bulk should consume a protein/carbohydrate meal or shake. Those looking to cut fat should wait as long as possible before eating and when you do, trying to eat high protein, low fat and low carbohydrate meals to allow the fat burning properties of GH to exhibit their full effect.

Recommended Diet
Bulking: For those trying to put on muscle mass, a diet high in protein and carbohydrates is recommended to be used in conjunction with your GHRP injections as insulin is required for Growth Hormone (GH) to be anabolic (muscle building).

Cutting: For people trying to lose fat, a diet high in protein, low in carbohydrates and moderate to low in fat is recommended since GH only exhibits its fat loss effects when insulin is not present.

Share with your friendsEmail this to someoneTweet about this on TwitterShare on Google+Share on FacebookPin on PinterestDigg thisShare on StumbleUponShare on TumblrShare on Reddit
eXTReMe Tracker