Tag Archive for IGF-1

Why it’s worth combining IGF-1 and Growth Hormone

igf-1

Bodybuilding peptide vial

Why it’s worth combining IGF-1 and Growth Hormone

 

The first argument that Janssen comes up with is that IGF-1 remains active for longer in the body if you inject it in combination with growth hormone. This is because IGF-1 is active for longer if it is attached to the binding protein IGFBP3.
If you inject IGF-1 on its own, the production of this binding protein goes down. But if you inject growth hormone and IGF-1 together, the concentration of this binding protein increases. That might mean that you would have to inject less frequently, as IGF-1 breaks down quickly in the body.

A second argument is that growth hormone makes the cells ‘ignore’ insulin. As a result, blood sugar levels rise, as does the insulin level. In the long run this might not be so beneficial to health, and it would inhibit muscle growth. If you use IGF-1 together with growth hormone, then the muscle cells become more sensitive to insulin. And that would mean more muscle protein build-up.

The advantage of combining IGF-1 and GH

 

is also a potential disadvantage, according to Janssen. On a molecular level the same processes involved in muscle growth are also found in cancer cells and tumors. The combination of both hormones might therefore give any tumors a growth stimulus. The same applies to other side effects such as undesirable growth of the jawbone, headache and trapped nerves in the hands.

In the final section of the article, the endocrinologist stresses that there have been very few studies on the effect of combined administration of GH and IGF-1, and that his article is mainly theoretical. “Determination of whether co-administration of GH and IGF-I is indeed superior to GH alone or IGF-I alone awaits further study”, concludes Janssen.

source: http://www.ergo-log.com/ghigf1.html

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Peptide mixing Information

Peptide mixing Information

Peptides come in the form of lyophilized (freeze dried) powder. The amount of powder/product is stated in International Units (IU’s) or in Milligrams (MG).
Melanotan peptides (Melanotan 1 & Melanotan 2), PT-141 Bremelanotide, GH Fragment, Ipamorelin, CJC-1295 & GHRPs (GRHP-2 & GHRP-6), HGH, HCG, et cetera use Bacteriostatic Water (BW). Bacteriostatic Water for injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% of benzyl alcohol added as a bacteriostatic preservative. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. The pH is 5.7 (4.5 to 7.0)

For IGF use an acetic acid solution (.6%) which is 7 parts distilled water and 1 part vinegar to reconstitute. You must filter the distilled water and white wine vinegar through a sterile 20 micron syringe filter before use. Sodium Chloride (NaCl) is used to buffer the injection.

1.) Take an alcohol swab to the stopper of both your peptide vial and the vial of the diluent.

2.) Draw your preferred diluent (BW) with a 1cc syringe. Choose an amount that will make measuring the final product simple.

1ml(cc) per 10 mg vial of Melanotan would mean each 10 tick marks on a U100 slin syringe would equal 1mg of Melanotan
1ml(cc) per 10 IU vial of HGH would mean each 10 tick marks on a U100 slin syringe would equal 1 IU of HGH

3.) Take the syringe with the diluent and push it into the vial of lyophilized powder letting the diluent dissolve the peptide. Many (not all) peptides are sealed with vacuum pressure, be careful.

4.) After diluent has been added to the vial, gentling swirl the vial until the lyophilized powder has dissolved and you are left with a clear liquid. The peptide is now reconstructed, ready for measurement and usage.
5.) Store your now reconstituted research peptides in the refrigerator.
Peptide Measurement
After successfully reconstituting your peptide, measure the desired amount out for injection. Use a U100 insulin syringe to draw out and inject your product.

Since you know the amount of IU’s/MG’s in your vial, we divide this out as follows:
You will need to know the following to be successful: 1ml = 1cc = 100 IU’s

We take our dose from the label of the dry lyophilized powder and we divide that into the amount of diluent used.

Example- We used 1cc(ml) of water. We have a 10 IU vial of HGH.
From our formula above we know that 1cc = 100 IU’s, so we have 100 IU’s of water.
We now divide the 100 IU’s (the amount of our water) by 10 IU’s (the amount of our HGH)
100 IU / 10 IU = 10

This 10 will perfectly correspond with the markings on a U100 insulin syringe. In our example every 10 mark on our syringe will equal 1 IU of HGH. Want to draw out 2 IU’s of GH? ….draw out to the 20 mark on the syringe (1/5th of the syringe).

Say you have a 1mg vial and you add 1ML you get
1000mcg/1mL: 10 mcg per IU
1000mcg/2mL: 5 mcg per IU

Say you have a 10mg vial and you add 1ML you get
10mg/1mL: 1 mg per 10 IU
10mg/2mL: .5 mg per 10 IU

Say you have a 20mg vial and you add 1ML you get
20mg/1mL: 2 mg per 10 IU
20mg/2mL: 1 mg per 10 IU

Say you have a 10iu vial and you add 1ML you get
10iu/1mL: 1 iu per 10 IU (on the syringe – 1/10th the product)
10iu/2mL: 1 iu per 20 IU (on the syringe – still 1/10th the product)

Say you have a 5000iu vial and you add 1ML you get
5000iu/1mL: 500iu per 10 IU
5000iu/2mL: 250iu per 10 IU

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