Tag Archive for IGF-I

MK-677 Restores Muscles, Fountain of Youth?

MK-677 Restores Muscles, Fountain of Youth?

A daily dose of MK-677 has been found to restore muscle mass in the arms and legs of older adults and improve some of their biochemistry to levels found in healthy young adults, suggesting an anti-frailty drug has been found.

The drug, called MK-677, was evaluated for its safety and effectiveness in a study that showed the drug restored 20 percent of muscle mass loss associated with normal aging. In fact, levels of growth hormone (GH) and of insulin-like growth factor I (IGF- I) in healthy seniors who took the drug increased to the levels found in healthy young adults, said Michael O. Thorner, a professor of internal medicine and neurosurgery at the University of Virginia Health System.

“Our study opens the door to the possibility of developing treatments that avert the frailty of aging,” Thorner said. “The search for anti-frailty medications has become increasingly important because the average American is expected to live into his or her 80s, and most seniors want to stay strong enough to remain independent as they age.”

Funded by the National Institutes of Health, the two-year, double-blind, placebo-controlled study involved 65 men and women ranging in age from 60 to 81. The results are detailed in the Nov. 4, 2008, issue of the journal Annals of Internal Medicine.

The MK-677 drug mimics the action of ghrelin, a peptide that stimulates a growth hormone called secretagogue receptor (GHSR). Drug developers are focusing on GHSR because it plays an important role in the regulation of growth hormone and appetite. They think it may prove to be an excellent treatment target for metabolic disorders such as those related to body weight and body composition.

Drugs found to work in early trials don’t always hold up to further testing, however.

The new research was a “proof-of-concept” study that sets the stage for a larger and longer clinical trial to determine whether MK-677 is effective in people who are frail and to assess its long-term safety.

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stimulation of growth hormone and IGF-I secretion by CJC-1295

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.
Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA.
Source




WinPharm Associates, Alamo, CA 94507, USA.
Abstract
CONTEXT:

Therapeutic use of GHRH to enhance GH secretion is limited by its short duration of action.
OBJECTIVE:

The objective of this study was to examine the pharmacokinetic profile, pharmacodynamic effects, and safety of CJC-1295, a long-acting GHRH analog.
DESIGN:

The study design was two randomized, placebo-controlled, double-blind, ascending dose trials with durations of 28 and 49 d.
SETTING:

The study was performed at two investigational sites.
PARTICIPANTS:

Healthy subjects, ages 21-61 yr, were studied.
INTERVENTIONS:

CJC-1295 or placebo was administered sc in one of four ascending single doses in the first study and in two or three weekly or biweekly doses in the second study.
MAIN OUTCOME MEASURES:

The main outcome measures were peak concentrations and area under the curve of GH and IGF-I; standard pharmacokinetic parameters were used for CJC-1295.
RESULTS:

After a single injection of CJC-1295, there were dose-dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 d or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9-11 d. The estimated half-life of CJC-1295 was 5.8-8.1 d. After multiple CJC-1295 doses, mean IGF-I levels remained above baseline for up to 28 d. No serious adverse reactions were reported.
CONCLUSIONS:

Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 microg/kg. There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC-1295 as a therapeutic agent.

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