Tag Archive for insulin-like growth factor I

Bodybuilding PEGylated MGF

Bodybuilding PEGylated MGF

I was originally going to wait until the end of my trail with PEG-MGF (herein further referred to as pmgf) before posting my results and information, but my PM box has been flooded with information requests, so instead of waiting, I am going to post a blog that will be updated weekly.

Let’s start with an explanation of Mechano Growth Factor (MGF) and what it does. The C-terminal peptide of mechano-growth factor (MGF), an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), was found to function independently from the rest of the molecule. At any rate, IGF-I exists in multiple isoforms (tissue-specific proteins of functional and structural similarity). One isoform, which differs from the systemic or liver type, happens to be particularly sensitive to mechanical signals such as the gamut of exercise overload. This important isoform, called mechano-growth factor (MGF), is a local splice variant of IGF-I produced by damaged or loaded skeletal muscle.

The physiological function of a recently cloned splice variant of insulin-like growth factor-I (IGF-I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.
Yang SY, Goldspink G. FEBS Lett. 2002 Jul 3;522(1-3):156-60.

So what is pegylation? In simple terms it is the process of attaching one or more chains of a substance called polyethylene glycol (PEG) to a protein molecule such as IGF or in this case MGF. Since the body does not react to PEG, it helps provide a protective barrier around an attached protein so it can survive in the body longer. This is highly beneficial for systemic products that must survive repeated attacks by enzymatic exposure. PEG is an inert non-toxic substance that can provide protection to amine groups since they are flexible and allow attachment by bioengineered processes to the receptor bearing cell.

Finally a quick explanation of polyethylene glycol; Any of a family of high molecular weight compounds that can be liquid or waxlike in consistency and are soluble in water and in many organic solvents.

Alright, now that you have sifted through my semi-scientific yet easy to read explanation of pmeg, let’s get to the main point of the article, my experience. First off, I was asked to test this new product. They supplied me the product and requested I use it at 200mcg, two times per week. I agreed on the condition that no matter what the results, good or bad, my review would be brutally honest. If they were looking for someone to just promote their product, I was not their guy. They agreed unconditionally and shipped the product out immediately.

Let me preface what follows below are my results but they will not be typical for most users. Having already accumulated up to 270lbs of mass over the years, my muscle memory is outstanding and I am easily able to rebound when using products. At this time, I have been off cycle for 2 months, using only 500mg test enanthate per week as HRT. This is my first time off cycle in over 8 years. I was also using 2iu gh per day but stopped using it at the request of IBE. My diet and training did not change, I was trying to create as stable an environment to test this product as would allow.

I started at a current bodyweight of 227lbs with my bodyfat measured at 14.8% and 55% water balance. I have some sophisticated test equipment at home so I can be sure my stats and my ability to track results are fairly accurate. I have been using this product for 4 weeks now, still having 4 weeks to go. After that, I will cycle off for a few weeks and then resume with a new test trial using mgf, igf, slin, and gh with small amount of anabolics in a very androgen rich environment. I will utilize many small injections with specific timing to maximize my results, but that is for another article.

My first week of use was a tough one for me, I had to come off the gh and immediately notice a decrease in lean mass, as well as longer recovery between workouts. This subsided very quickly though with the introduction of pmeg. My current workout schedule is on Tues, Thurs, and Friday. I decided to use the pmeg on Tues and Thurs, my two biggest bodypart workout days. I was instructed by IBE to test it sub-q since it is systemic anyway and the injection method was somewhat irrelevant. On my next trial, I will be using it IM in a specific sequence with other peptides.

My first week of use, my weight stabilized as did my body fat percentage. I was quickly able to stop my wasting from coming off cycle and gh, and reintroduce beneficial cell growth potential. The changes from my first to second week were dramatic to say the least. Not only was I getting skin tight pumps, my vascularity was up, but the scale was most telling off all. I went from 227lbs to 232lbs by the end of the second week. At this time my water balance and body fat were still the same. The third week was another major change, even more so than the first two weeks. My weight jumped up to 235lbs but most incredible of all was the fat loss. Let me remind you that I did not make any diet changes; I just added this product in mostly as a pct product while coming off cycle. So what impressed my most was my body fat dropping from 14.8% to 12.9%. I just finished my 4th week yesterday so I jumped back on the scale to see what changes were in store for me now!

This was the best week yet. Before you get all freaked out, please remember that I just came off an 8 year cycle, my body fat jumped up from the estrogen increase and I was gaining back weight I had lost from not bulking anymore. Ok, with that out of the way again, here is week 4: Weight backed off a bit to 234lbs, but my body fat melted down to 10.9%, a drop of almost 4% since starting this just 4 weeks ago. The other awesome gain was my cellular water balance was up to 58% which is an indication of intra-cellular water balance for overall health, condition, and prevention from muscle and joint tissue damage.
PegMGF Journal by “Almost Pro”
My Pegylated Mechano Growth Factor trial
By Gavin Kane

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MK-677 Restores Muscles, Fountain of Youth?

MK-677 Restores Muscles, Fountain of Youth?

A daily dose of MK-677 has been found to restore muscle mass in the arms and legs of older adults and improve some of their biochemistry to levels found in healthy young adults, suggesting an anti-frailty drug has been found.

The drug, called MK-677, was evaluated for its safety and effectiveness in a study that showed the drug restored 20 percent of muscle mass loss associated with normal aging. In fact, levels of growth hormone (GH) and of insulin-like growth factor I (IGF- I) in healthy seniors who took the drug increased to the levels found in healthy young adults, said Michael O. Thorner, a professor of internal medicine and neurosurgery at the University of Virginia Health System.

“Our study opens the door to the possibility of developing treatments that avert the frailty of aging,” Thorner said. “The search for anti-frailty medications has become increasingly important because the average American is expected to live into his or her 80s, and most seniors want to stay strong enough to remain independent as they age.”

Funded by the National Institutes of Health, the two-year, double-blind, placebo-controlled study involved 65 men and women ranging in age from 60 to 81. The results are detailed in the Nov. 4, 2008, issue of the journal Annals of Internal Medicine.

The MK-677 drug mimics the action of ghrelin, a peptide that stimulates a growth hormone called secretagogue receptor (GHSR). Drug developers are focusing on GHSR because it plays an important role in the regulation of growth hormone and appetite. They think it may prove to be an excellent treatment target for metabolic disorders such as those related to body weight and body composition.

Drugs found to work in early trials don’t always hold up to further testing, however.

The new research was a “proof-of-concept” study that sets the stage for a larger and longer clinical trial to determine whether MK-677 is effective in people who are frail and to assess its long-term safety.

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