Tag Archive for Insulin-like Growth Factor

MGF + IGFr3 bodybuilding peptide cycle

MGF + IGFr3 bodybuilding peptide cycle

Mechano Growth Factor (MGF). We know things like IGF creates new muscle cells and helps drop body fat and MGF helps facilitate this muscle growth and fat loss.

Most of us are familiar with the peptides Insulin-Like Growth Factor (IGF) and In Mechano Growth Factor (MGF). We know things like IGF creates new muscle cells the beginning:

When IGF first made its way onto the bodybuilding scene most people were injecting it every day and noticed that after somewhere around 30 days the effects of IGF wore off. This was blamed on receptor “down-regulation” or “desensitization”. To combat this people started a 5-on 2-off rotation and then went to a post workout only rotation which extended the time on IGF an additional 10-20 days. But the problem with the lack of “receptor response” was still present.

Then MGF came onto the scene. MGF was suppose to be the next best thing in bodybuilding. It was suppose to be more anabolic than AAS and better suited for building new muscle than IGF, the problem was that it wasn’t. Because of its instability it was quickly broken down once injected into the body, to prevent this Peg-MGF was created. This new MGF was now able to survive in the body from anywhere in the 1-3 days. Combining this new peptide discovery with IGF was suppose to be able to make all of us the next Mr. Olympia. But what happened? Why do we not see a flood of new pros?

What happens when both MGF and IGF are used together:

In theory these two peptides should cause some great results, the problem is they do not work together very well unless your timing is spot on (I will go into greater detail later). In short stem cells in the presence of MGF will cause the cells to split and multiply. When the cells are multiplying they cannot form new tissue and the effects of IGF are completely blocked. So the two together are not very compatible.

Then why not just use IGF? Well most do use IGF only and get great results, but there is that pesky business of receptor “down-regulation” or “desensitization” and you have to end a cycle of IGF after 30-50 days and there is no way to prevent it… or is there?

The science behind using MGF and IGF:

In a natural system (Our Body) we have peaks and dips with MGF and IGF levels. The reasons for these peaks and dips are to create the ideal amount of cells to repair and create new tissue. After strenuous exercise the levels of MGF in the body (more specifically in the muscle just trained) increase dramatically and there is a dramatic decrease of IGF levels. The reason for this is because MGF causes stem cells to proliferate (split and multiply). This process ensures that there are enough cells available to make repairs and to create new tissue in order for the tissue to function efficiently and properly (in this case skeletal muscle tissue). As mentioned above in the presence of MGF there is no need for IGF because it is rendered useless and cannot activate the stem cells, so this explains the bodies response to decrease IGF levels.

In 12-36 hours MGF levels begin to drop and there is a direct correlation in the rise of IGF levels within the body. Stem cells have proliferated and now the IGF will bind to the proper receptors and cause differentiation (force the stem cells to form into a specific cell for a specific tissue type). This process repeats every time you exercise and keeps the natural system in an efficient state.

When flooding the body with these artificial bodybuilding peptides a person will change this natural system dramatically. A person using MGF only is causing stem cell proliferation while at the same time preventing IGF to perform its duties of creating new tissue from those newly created stem cells. A person using IGF only is depleting the supply of stem cells at a rate much faster than the body can keep up, leading to a depletion of available stem cells and not receptor “down-regulation” or “desensitization.”

This sounds like a lose-lose situation. You are throwing off your body’s final tuned muscle repairing mechanism, depleting valuable stem cells or creating too many stem cells for your body to deal with. Why bother?

The climax:

The reason why we bother is because we want to reach or goals. We want to be the biggest bodybuilder, the best powerlifter or whatever it is that we are training so hard for. These Bodybuilding peptides are a great addition to our arsenal, but learning to use them properly is the key to utilizing their benefits.

The key is retraining the way we think about MGF and IGF. We have to understand that we are dealing with the creation and depletion of stem cells that are going to be responsible for our muscular growth. Our bodies do not have a constant supply of these stem cells and our bodies will not naturally utilize all of the stem cells it has created. Since we are trying to artificially manipulate the amount and utilization of these stem cells we have to look at this is a different manner.

While we may never get the exogenous MGF and IGF levels just right so that we may counteract the depletion of the stem cells we can adjust our protocols in a way that will increase the amount of time a person can use and respond to both peptides.

The Conclusion Part 1, MGF:

We know that the PegMGF will stay in the body for several days and we know that while in the presence of MGF stem cells will proliferate and the use of IGF is futile. We also know that MGF without the peg is of little to no help because of how quickly exogenous MGF is broken down within the body. So what are the options?

Well both can be of use!  Peg-MGF can be of great use as long as the individual using the peptide in conjuction with IGF understands that the two peptides must be injected in a manner that falls outside of the current way of thinking. And MGF without the Peg addition can also be utilized as long as you don’t mind being a pin cushion.

The key with MGF is to learn to either follow your bodies natural peaks and dips of MGF levels and force proliferation on a larger scale with MGF, or to force a longer period of cell proliferation with the use of PegMGF. The key is you have to have stem cells in order to create new muscle tissue.

The Conclusion Part 2, IGF:

Now that we have hit the MGF part of the cycle, now we move into the part of the cycle that utilizes the stem cells. Again we want to either follow the body’s natural peaks and dips of IGF levels or we are going to want to cause a prolonged forced differentiation phase. The latter of the two options is simply following standard protocol of everyday injections or 5-on 2-off. The other is all about timing. We know that MGF levels peak in the body after strenuous exercise, so why would you want to inject a substance that is useless in the presence of MGF right when MGF levels are at their highest? The answer is you don’t! You will want to wait and inject the IGF 24hrs after the exercise. This will give ample time for the MGF peak to start to dip and can closely mimic the natural rise in IGF levels. This will allow for a person to use a more efficient dose since the timing of the IGF will correspond closely to the dip in MGF levels resulting in greater utilization of the exogenous IGF.

The Peg-mgf, igf-1r3 cycles:

There are a few cycles I would recommend.

The first being IGF only. It works, maybe not the most efficient plan out there but it does work none-the-less.

The second would be the Peg-MGF/IGF combination. This is not the most efficient methos but should significantly increase the amount of time one can be on an MGF/IGF cycle and still see positive results. (This may have to be altered according to your training schedule)

Sunday – Off Training – Mid-day Peg-MGF 200-300mcg
Monday – Training (Afternoon)
Tuesday – Off Training – Afternoon IGF 40-80mcg
Wednesday – Training (Afternoon)
Thursday – Off Training – Afternoon IGF 40-80mcg
Friday – Training (Afternoon)
Saturday – Off Training – Afternoon IGF Injection 40-80mcg

The addition of the Peg-MGF will cause an increase in amount and duration of stem cell proliferation and should subside about the period of the first IGF injection. While this will not keep stem cell levels stable it should prevent the drastic decrease in stem cell numbers seen with IGF only cycles and should significantly increase cycle length.

The third would be the use of regular MGF plus the addition of IGF and woulld closely mimic the natural system.

Sunday – Off Training
Monday – Training (afternoon) – 1hr PWO MGF 50mcg in muscles trained
Tuesday – Off Training – Afternoon IGF 40-80mcg
Wednesday – Training (Afternoon) – 1hr PWO MGF 50mcg in muscles trained
Thursday – Off Training – Afternoon IGF 40-80mcg
Friday – Training (Afternoon) – 1hr PWO MGF 50mcg in muscles trained
Saturday – Off Training – Afternoon IGF 40-80mcg

This protocol should closely mimic natural peaks and dips in MGF and IGF within the specific muscles being trained. While regular MGF is short lived in the body the addition on the regular MGF 1 hour post workout should cause an increase in cell proliferation beyond the natural system’s ability and should create a larger pool of stem cells for the utilization of IGF therapy.

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Your guide to Peptides

Most if not everything you need to know in relation to research peptides..

Afamelanotide  (M-I)

Melanotan One, Scenesse, Afamelanotide (M-I)
Dosing:

Light: .5mg
Common: 1mg
Large:
2mg

Melanotan/Afamelanotide is a synthetic version of melanocyte
stimulating hormone (a-MSH). Afamelanotide has been shown to induce skin
pigmentation through melanogenisis, the production of melanin. Melanin prevents
cellular damage in the skin by absorbing, reflecting and refracting light.
Melanotan reduces sun damage to UV exposed skin in those with sun allergies.

Melanotan
favors production of eumelanin (black/brown) over pheomelanin (red/yellow)
pigment. Injecting this linear amino acid structure peptide offers
super-physiological levels of a-MSH. Learning the majority of secretion of a-MSH
comes from the skin as opposed to the pituitary gland was a recent breakthrough
in medical science. Those with a Fitzpatrick skin type I-III classification have
natural levels of a-MSH that are hardly detectable. The fair skinned can achieve
a photoprotective tan with synthetic MSH.

The
half-life of Melanotan peptides is very brief. Afamelanotide is being developed
in implant form for the ease of use in dermatology. The implant contains 16mg
which has a controlled release effecting melanin density for months. Melanotan
One is offered in research peptide form (20mg Melanotan One). Peptide Melanotan
One gives the user greater control over dosing, however requires a series of
injections and expertise. Missing a dose or taking time off is okay.
Intermittent therapy, lasting 10 days (skin type III) to 6 months (skin type I)
is typical for researchers.

Two
amino acids present in the bodies natural a-MSH have been changed in production
of Afamelanotide creating a more stable molecule.
Amino acid sequence:
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

Melanotan is
still undergoing clinical trials and has not reached approved status. People use
on the pretenses and understanding that it is for research purposes only. Users
may suffer from slight nausea and flushing after subcutaneous injection; however
it is reported to be mild and pass quickly.

Melanotan One is a selective
agonist of the MC1R (Melanocortin 1 receptor) and does not have aphrodisiac
effects. Melanotan One does not cross the blood brain barrier (BBB). It is for
this reason Afamelanotide has continued clinical trials. The fat/weight loss,
appetite suppression, libido effects are found in Melanotan 2 and Bremelanotide
(PT-141).

Melanotan One is less efficacious than its counterpart
Melanotan 2 for achieving a dark tan. Afamelanotide will therefore require 8-10x
the dosage to see comparable results. Melanotan One users want minimum side and
peripheral effects with a focus on photoprotection.

Administration of
Research Melanotan
Safe and controlled administration of Afamelanotide for
research is done much like that of Melanotan 2. Melanotan One offered as a
peptide in a multi-dose sterile vial is desirable. Implants, nasal sprays and
pills are not applicable/efficacious at the present time.

The Melanotan
“Cycle”

Allow time before seeing UV exposure. Sunburn is to be avoided.

Example- Skin type II, 180lb male
Day 1-2: .5mg each night
Day
3-6: 1mg when convenient
Day 7-10: 2mg when convenient
Day 11 on forward:
begin dosing ~6mg/week

Day 7: 10min sun bed session. (Cover
face/genitals/sun damage, use lotion, etc)
Day 9: 10min sun bed session.

Day 11: 15min sun bed session

Dosing According to Skin
Type

Fitzpatrick Skin Type I: 1mg-2mg/day. 100mg total may be necessary
to achieve desired color. UV exposure after at least 20mg in
system
Fitzpatrick Skin Type II: .75mg-1.5mg/day. 60mg should be sufficient
to get color. UV exposure after 10-20mg
Fitzpatrick Skin Type III:
.5mg-1mg/day. A sunless tan may be realistic here
Fitzpatrick Skin Type IV
and beyond: Do not use Melanotan

Melanotan can develop a protective tan
in users. A natural tan is developed in response to cell damage caused by UV
radiation. Ultraviolet rays penetrate the upper layers of the skin, triggering
a-MSH, stimulating melanin production. Melanin deposits act as a natural
sunblock at the cellular level. Melanotan injections may offer a way to bring
upon a safe, cosmetic tan with less damage.

Melanotan Results

Reconstituting

Swab
the stopper of both your M-I vial and the vial of the dilutent (bacteriostatic
water) with an alcohol swab.

Take a syringe and draw up your bact water.
The amount isn’t critical, other than making sure you know exactly how much you
have used. The best rule of thumb is choose an amount that will make measuring
the final product easy.

Example- 2ml(cc) per 20mg vial of M-I would mean
each 10 marks on a U100 insulin syringe would equal 1mg of Melanotan
(M-I)
Example- 1ml(cc) per 10mg vial of M-I would mean each 10 marks on a
U100 insulin syringe would equal 1mg of Melanotan (M-I)

Avoid shooting
the dilutent directly on the lyophilized powder. The powder should almost
instantly dissolve. Gently swirl until the liquid is clear if powder did not
dissolve upon contact.

Store your unused M-I in the refrigerator. Once
reconstituted, the Melanotan should be good for 4-6 weeks in the refrigerator.

Measuring

After successfully reconstituting your peptide, now
measure the desired amount out for injection. You will want to use a U100
insulin syringe to draw out your M-I.

Since you know the amount of mg’s
in your M-I vial, and you also know how much water you have diluted it with, we
just divide this out as follows:
Note: 1ml = 1cc = 100 IU’s

So we take
our number of mg’s of Melanotan and we divide that into the amount of dilutent
we used.

Example- We used 2cc(ml) of water. We have a 20mg vial of
M-I.
From our formula above we know that 1cc = 100 IU’s, so we have 200 IU’s
of water.
We now divide the 200 IU’s (the amount of our water) by 20mg (the
amount of our M-I)

200 IU / 20mg = 10

This 10 will perfectly
correspond with the markings on a U100 insulin syringe. In our example every 10
increments (1/10th of the syringe) on our syringe will equal 1mg of M-I.

Melanotan 2
(MT-II)

Melanotan 2 Dosing:

Light: .5mg
Common:
1mg
Large: 1.5mg

Melanotan 2 (MT-II) is an analog of alpha-melanocyte
stimulating hormone (a-MSH). Melanotan 2 comes in the form of a freeze dried
(lyophilized) peptide in a sterile multi-use vial.

Melanotan
2 acts on melanocytes to stimulate melanin production. Melanin is the body’s
natural pigment responsible for your tan.

Melanocortins
are a family of peptides beginning with the sequence: His-Phe-Arg-Trp. Melanotan
peptides bind to and activate melanocortin receptors (MCRs) which influence
pigmentation, inflammation, energy homeostasis, appetite and sexual function.
MT-2 MCRs: MC1R, MC3R, MC4R & MC5R.

Melanotan 2 is a smaller and more
potent than M-I (which targets MC1R) targeting more receptors. Melanotan 2 has a
protective ring-like amino acid structure as compared to a linear peptide such
as Melanotan One or Afamelanotide.

What
does this mean? The fair skinned CAN achieve a natural tan with synthetic MSH,
Melanotan 2. For people with sun allergies these discoveries are life changing.
The best defense against skin cancer is a natural tan developed over time. MT-2
was designed to reduce skin cancer rates and be effective as a sunless
tanner.

Who uses Melanotan 2? Athletes and fitness enthusiasts choose
MT-2 as a lifestyle product to increase tanning efficacy, the aphrodisiac and
appetite suppression. MT-2 was dubbed the Barbie drug and has been highlighted
in wired. Synthetic melanocortin use helps to attain a tan with the least amount
of exposure to harmful ultraviolet radiation (UVR).

Lower
skin types on the Fitzpatrick scale are the best candidates for Melanotan
2.

Melanotan
treatment stimulates melanin effectively, in particular those with low skin
types.

Note:
Melanotan is approximately 1,000 times more potent than natural a-MSH and MT-2
has a greater efficacy than M-I.

Disclaimer: Please pursue information
regarding the usage of these products from your own research, academic journals,
or the research of your in-house scientific team. Products are sold for research
purposes are not for human consumption. Remember when you contact these types of
stores/sponsors not to relate the questions or topics to human
consumption or they tend not to answer. Always inquire in a research type
question.

Melanotan 2 Peptide: Melanotan 2 peptides come in 5mg and 10mg
sizes. Photograph at left shows a 5mg and 10mg MT-2 peptide as an example.
Peptides within photograph were synthesized by the same laboratory, contain no
filler and therefore volume reflects content. All peptides and freeze drying
processes are not created equal. Current MT-2 industry standard is the 10mg, 2ml
vial size. Trending towards lower doses, freshness, safety, travel and other
factors are increasing demand for smaller quantities.

Reconstituted with
bacteriostatic water (BW), MT-2 peptide remains potent and preserved.
Reconstituting (mixing) your Melanotan 2 peptide is a necessity and will require
proper due diligence for results. Nasal sprays, pre-mixed Melanotan 2, pills,
oral and loose powder are not often legitimate. There are successful reports of
nasal spray experiences, however, they are few and far between as the molecule
is larger than the membrane will allow. Enzymes will render the peptide inactive
if ingested.

Shipping and Handling: Melanotan peptides are durable and
stable. Highlighted in study, the reconstituted MT-2 was shown to be stable at
37 degrees Celsius (98 degrees Fahrenheit) for at least 28 days. Shipping MT-2,
even in summer months, is not a problem. Do not pay for cold shipping as it is
not a premium. When receiving MT-2 it is recommended to store in the
refrigerator.

Mixing: Add BW to the vial when you are ready to begin
MT-2 research. View the instructional youtube video on the PT-141 page to see
the reconstitution process.

Remove plastic flip top from vial to expose
rubber stopper. Needle will pierce the stopper making way inside the vial to
turn the white powder into a clear liquid.

Calculator: Add 100 units
(1ml) of water to the vial. 1ml/100 units will minimize the volume that you have
to inject and will simplify the arithmetic in your MT-2 experiment.

1ml syringe (U100), 1ml BW to reconstitute
Calculations for a
desired 0.5mg/500mcg dose:
Step 1= 1ml
Step 2= 10mg MT-II
Step 3= 1ml
bact water
Step 4= 500mcg dose
2-3 ticks on your insulin pin
(approximately 1/20th of a U100 syringe)

Some
prefer to add more dilutent which works fine, take note of the volume increase.

Needles: 29-31 gauge X 1/2″, 1 CC (100 unit). That is a typical insulin
needle used to mix as well as inject. Use needles one time only. Once your
technique perfected, injections are almost painless.

Starting dose: Your
first injection should be a very small dose, for example .25mg (250mcg). See how
you react. Goal should be to feel nothing. Dose after dinner, before bed. Any
dosing chart stating that you should take a high dose (according to your weight)
is outdated and potentially dangerous.

Loading dose: Load with 0.5-1mg
once a day. People who have used doses in this range generally report getting
excellent results. Don’t worry if you miss occasional days. It will not make
much difference, focus on the cumulative effects.

Maintenance dose:
Maintenance is taking doses less frequently than daily to avoid becoming darker
than you want. Yes, that will happen. With enough UVR, you will get much darker
than you have even been before. A maintenance dose can help prolong
super-physiological photo-protection MT-2 delivers.

UV Radiation:
Melanotan is a poor sunless tanner. UV (from sun or a tanning bed) light is
necessary to develop a tan. Without it, almost nothing happens. In other words,
NO UV = NO TAN. Well, user will pigment depending on skin type…. If you have
loaded for a full month and then start UV exposure, you (and your friends) will
be astounded by how fast you tan and how dark you get. Moreover, it is advisable
to keep areas of your skin that ordinarily get exposure covered up with a towel
and/or zinc oxide (nose/lips/face) and let less exposed areas develop
pigmentation first. Areas of skin that are typically sun-exposed in your day to
day life will respond more readily to the effects of the melanotan
peptides.

Fat Loss: The melanocortin (MC) system is a signaling pathway
for leptin and insulin. The MC system is important for control of food intake
and body weight. MT-2 treatment results in adipocyte lipolysis. MT-2 increases
fatty acid oxidation(FAO) in which the MC5R plays a significant role. MT-2
improves insulin sensitivity through stimulating FAO in skeletal muscle tissue.
Reduced food intake from the anorectic response of MT-2 is primarily responsible
for weight loss.

Watch yourself: Your tan can sneak up on you. A tan
generally sets in 3 days after UV rays. Dose and expose yourself gradually to
UVR when tanning. Love your skin.

Avoid burning: You are protected from
burning mostly by your tan, not the MT-2 peptide. Therefore, don’t overdo the
rays at first. Start with only as much UV that you could tolerate without
burring before you began Melanotan. It should not take many weeks before you can
tolerate hours of strong sun without burning. Truly incredible for those who
have never experienced freedom to enjoy the sun.

Continue your regular
dosing protocol until you have reached your desired tan and do not want to
become darker. Cut injection frequency to once every 2, 3, 4, or even 7 days.
Experiment to find the frequency that gives the tan you want.

Storage:
Store freeze dried and reconstituted peptides in the refrigerator.

Do you
have to inject MT-II?
Yes. The best, most efficient method of administering
Melanotan peptides are subcutaneous (subq) injections. Nasal sprays are
inconsistent and inefficient. No detectable levels were observed following oral
dosing – pills do not work.

Note:
There are many things you will need to consider before experimenting with this
peptide. Cyclic analogues (MT-II) have a wide range of peripheral effects and
systemic control is always going to pose an issue in clinical use. Needless to
say, MT-II is not an approved or regulated product. MT-II is legal to buy,
possess, etc. Variables such as skin type and individual goals need assessment.
Ask for critiques, plans and create a user log during use. Seasoned users are
generally more than happy to offer tricks of the trade.

When you start
supplementing a-MSH to tan keep in mind that tanning is literally a side effect.
The tanning response is, in reality, a physiological repair mechanism to instant
UV damage of the skin cells (epidermis/dermis). Melanocyte stimulating hormone
is not going to color your skin, it is going to make your own skin create its
own tan and that in turn creates protection. If you are looking to be some
bronzed beach God with perfectly uniform and specific color then you are better
off to going to mystic tan. Redheads, for example, naturally produce a variant
form of melanin that is yellowish-red (pheomelanin). Do not expect a brown tan
on a ginger body right away.

Know your skin type: Knowing your skin type
is just one detail which will help create a user log. There are 10s of thousands
of melanotan users worldwide who share the experience. Raise awareness and help
others who want to hear success stories, complications and failures.

Am
I a good candidate for MT-II?
Melanotan is best suited for the folks with
skin types I & II. Prior sun damage, scars, tattoos, freckles, moles, hair
color, etc are deciding factors prospective MT-2 users consider. This is a
question handled best through asking the audience.

How should I dose
MT-II?
Start out small and build up. A typical starting dose is around .25mg
and max dose reaching 1mg.

Things to consider: There is no magic pill or
formula. Few dermatologists are familiar with Melanotan. The skin is a large,
unpredictable organ. Feel comfortable and confident with MT-II before use. Check
out as many before and after photos and user logs as you can. A skin type I
individual may have to commit months of dedication before dialing in their
desired results, be patient.

How much MT-II should I buy and how long
will it last?
Skin type I: 30-50mg
Skin type II: 20-30mg
Skin type III:
10mg
Should last entire summer or season

How soon will I begin to see
results?
You should notice a change in your skin tone after three weeks. If
you have freckles, expect them to get darker before your actual skin color
changes.

How long will tan last?
A tan developed using Melanotan 2
lasts much longer than an ordinary tan. A well-tanned person returning from a
beach holiday will lose most of the tan in a month if they stop getting sun. But
if they had been using Melanotan 2 and continued on maintenance after returning,
they would still have most of their tan 3 months later.

Side effects of
MT-II?
Possible short-term side effects you should know about, including:
nausea, appetite loss, facial flushing and increased libido. These may be
noticeable during the first few days of treatment but should taper
off.

Dosing an anti-histamine, such as Claritin (Loratadine), works to
eliminate sides such as nausea after injecting.

Bremelanotide (PT-141)

Bremelanotide PT-141
Dosing:

Light: .5mg
Common: 1mg
Large: 2mg

Bremelanotide
(PT-141) was developed from Melanotan 2 (MT-II), which was tested as a sunless
tanning agent. PT-141 is a metabolite of MT-II that lacks the C-terminal amide
function-stripping away tanning properties.

Studies
have shown bremelanotide to be effective in treating sexual dysfunction in both
men (erectile dysfunction or impotence) and women (sexual arousal disorder).
PT-141 is the only synthetic aphrodisiac. Unlike Viagra and other related
medications (PDE5s), PT-141 does not act upon the vascular system, but directly
increases sexual desire via the nervous system
(hypothalamus).

Bremelanotide is a melanocortin peptide hormone. PT-141
binds to the melanocortin 4 receptor (MC4R) in particular. Nine out of ten
volunteers experienced sexual arousal in trials. The desire is one of the more
sought after effects unique to the peptide.

Window of
Opportunity:
Although injected (subcutaneously), Bremelanotide has a unique
window of opportunity lasting six to 72 hours. In lab trials, female rats
exposed to PT-141 immediately began “flirting” with male rats for sex. Postures
and movements left no doubt in the male rats minds that they were in the
mood.

Women who took part in trials said that they felt a “tingling and a
throbbing” along with “a strong desire to have sex.” An initial flush occurs
post injection, followed by nausea which is dose dependent. For most, effects
generally do not take place until a couple hours post injection, peaking around
the four hour mark.

Men said PT-141 made them feel “younger and more
energetic” as well as sexually interested and aroused. “You’re ready to take
your pants off and go,” said user “a drug that makes you not only able to but
eager to.”

Dosing: Read as much as possible to gain clarity and align
expectations. Gradually dosing increases likelihood for success without sides. A
test dose of .25-.5mg on the first attempt is recommended. 1mg, give or take a
quarter, is the efficacious dose which yields the most hero stories reported by
users.

Bremelanotide PT-141 Peptide:

Bremelanotide
in lyophilized form comes in 10mg and 2mg vial sizes (as pictured above -notice
the peptide volume -no filler present). Once reconstituted with bacteriostatic
water, PT-141 can be stored in the fridge for a couple months and remain potent.
Nasal sprays, pre-mixed PT-141, pills and loose powder are not legitimate forms
of Bremelanotide. There are successful reports of snorting and nasal spray
experiences…however they are few and far between.

Mixing:
Bacteriostatic water is used for reconstitution.

Example- 1ml(cc)
bacteriostatic water per 10mg PT-141 vial equates to a 1mg dose approximately
each 10 units on a U100 insulin syringe.
Example- 1ml(cc) bacteriostatic
water per 2mg PT-141 vial equates to a 1mg dose approximately every 50 units on
a U100 insulin syringe.

Recommended strategy for mixing and dosing would
be to reconstitute with the volume that yields a .1ml injection.

Example- 1ml(cc) bacteriostatic water per 10mg PT-141 vial equates to a
1mg dose approximately each 10 units on a U100 insulin syringe.
Example-
.2ml(cc) bacteriostatic water per 2mg PT-141 vial equates to a 1mg dose
approximately every 10 units on a U100 insulin syringe.

Human Growth Hormone (HGH)

Human Growth Hormone
(HGH) Dosing:

Month 1: HGH 2 IU one injection every other day
Months
2-4: HGH 3 IU one injection five days a week
Months 5-6: HGH 4 IU one
injection five days a week
4-6 month cycles are optimal, year round if you
are over age 35.

Human Growth Hormone (rHGH, HGH, or GH) is a protein
molecule consisting of 191 amino acids. Genetically engineered recombinant human
growth hormone is completely identical to the growth hormone made by the human
pituitary gland. Researchers have proven growth hormone therapy can reverse the
biological effects of aging. HGH is widely appreciated for aesthetics, not
necessarily as a performance enhancer.

HGH is released in pulses
that take place during the day. Growth hormone is rapidly converted in the liver
to its powerful growth promoting metabolite, Insulin like Growth Factor. IGF-1
is measured in the blood to determine the level of growth hormone secretion.
Most of the beneficial effects of human growth hormone are directly attributable
to IGF-1. Growth hormone replacement/stimulation is the most effective therapy
to reverse the effects of aging.

At age 30 people have people have
spent most of their lives with relatively high levels of HGH. HGH is responsible
for growth during childhood as well as for repair and regeneration of tissue. By
the time we are 30 our bodies no longer naturally produce enough GH to handle
the damage that is taking place. As this continues, we age. Increasing HGH in
our bodies, we can slow, or even reverse many of the manifestations of aging.

What HGH can do:

* Reduce excess body fat, especially abdominal
fat. (The reduction of abdominal fat is the single most profound effect of HGH
replacement in many people)
* Decrease in the waist to hip ratio. (Meaning
fat is removed primarily from around the waist where it is associated with a
high risk of coronary disease)
* Increase muscle mass. (and physical strength
if combined with moderate exercise)
* Reduce wrinkling of the skin and some
other effects of skin aging. (Compliments can be Melanotan and MT-II)
*
Re-grow certain internal organs that have atrophied with age.
* Increase bone
density.
* Strengthen the immune system.
* Enhanced feeling of well
being.
* Reverse cognitive decline.
* Stimulate production of the bone
marrow cells that produce red blood cells.
* Reduce the probability that you
will spend the last years of your life in a nursing home.
* HGH slows the
progression of cardiovascular disease, and reduces the risk of death from
cardiovascular disease, in individuals with natural growth hormone levels that
are below average for the age of the individual. HGH can also slow the
progression of cardiovascular disease by improving one’s cholesterol profile.
There is increasing evidence over the past year or two that maintaining healthy
growth hormone levels results in a stronger heart. Individuals with low growth
hormone levels have an overall increased risk of death due to cardiovascular
disease. Low growth hormone levels cause a particularly large increase in the
risk of stroke as compared with individuals receiving growth hormone
replacement.

HGH takes several weeks to months of use benefit from
its effects. There are a number of substances that increase the natural
secretion of HGH. Some of them are amino acids. The relationship of certain
amino acids to growth hormone is complex and varies greatly among different
individuals and among individuals of different ages. All absolute and universal
statements made about this subject are clearly false.

HGH is a
peptide that comes in the form of lyophilized powder. Any other form that you
see advertised or run across is likely NOT the real deal. The only way to
administer true HGH is by sub-q or intramuscular injection. Be aware that HGH is
not anabolic by itself. Careful measures need to be in place during
reconstitution.

Reconstituting common HGH, one vial contains powdered
freeze-dried HGH and the other vial contains sterile water with a bacteriostatic
preservative. When the user is ready to begin, a certain amount of the sterile
water is drawn out of the second vial (with a needle and syringe) and injected
into the first vial to dissolve the powdered HGH. The solution is then ready for
injection. The unused portion is to be kept refrigerated. Use reconstituted HGH
within 3 or 4 weeks.

HGH peptide is dissolved by the user because HGH
powder is much more durable. The dissolved HGH is very susceptible to being
attacked by bacteria and degraded by enzymes. HGH is normally refrigerated, but
if HGH powder is is left at room temperature for a few hours, no harm is done as
long as the room is not too warm. Sterile powdered HGH can even be left in a
cool room for days or weeks, but this is not a good idea. Even the powdered HGH
can deteriorate if the temperature rises slightly above normal room temperature
for any significant period of time.

The best way to begin HGH is to
start with a low dose and ease your way into higher doses. This will allow you
to avoid (or at least minimize) many of the more common sides of HGH such as
bloating and joint pain. Most can tolerate 1-2 IU per day with few sides. HGH
administration should be done on an empty stomach as fats and carbohydrates
blunt release. Natural production of GH is 1 IU, give or take a half. For
results in athletes the dosing should attempt to duplicate how the body releases
the hormone naturally. Learning how much and when to best dose is very
individual. My apologies for the dosing chart above.

For bodybuilders
growth hormone is best taken in conjunction with insulin, anabolics/androgens,
and thyroid hormone. Insulin is extremely effective with HGH as the injections
cause a down regulation of insulin sensitivity in the body.

Half
life of HGH is 2 hours when injected sub-q with a four hour period which there
is a suppression of naturally produced GH. Intramuscular injections shorten the
half life. Subcutaneous injections over the long term can lead to spot
reduction. Whether or not HGH has any localized benefit from IM injection is
unknown, but speculated.

HGH is tightly regulated by the FDA, but HGH
is not a controlled substance on the federal level in the United
States.


Insulin-like Growth Factor (Long-R3-IGF-1)

IGF-1 (Long R3 IGF-1)
Dosing:

Light: 20 mcg
Common: 40 mcg
Large: 80 mcg

IGF-1 is
injected post work out (PWO) or in the AM on non workout days for 4-6 week
intervals

Insulin-like Growth Factor (Long-R3-IGF-1), an 83 amino
acid analog of IGF-1 is a highly anabolic hormone released primarily in the
liver with the stimulus of growth hormone (HGH).

Freeze
dried (lyophilized) IGF-1 (in powder state) should be stored in the freezer (-18
degrees celsius).

Each Long r3 IGF-1 kit contains:

* 1000mcg
of lyophilized Long R3 IGF-1
* 2 mls of 0.6% Acetic Acid (AA)
* 30ml
Sodium Chloride (NaCL) as buffer

Dilute the IGF-1 with 2mls of Acetic
Acid. Assuming (*DO NOT ASSUME*) AA will yield the correct pH balance of your
research peptide.
Note: This creates a concentration of 500mcg/ml. So each
1/10 of a ML is 50mcg’s.

Draw the desired amount of IGF in to a syringe.
Desired amount should be the approx dose you want to take.
Example- 2mls AA
used to reconstitute IGF-1 1mg vial means 5 units on a U100 insulin syringe
would equal 25mcg IGF-1
Pre-load your syringes at 5iu (25mcg IGF-1). Divide
your IGF-1 into 20 syringes to move to the freezer for storage.

Thaw
prior to administration. Draw from your NaCL after thawed to fill the remainder
of your syringe with the buffer (up to 1ml typically).

Administer your
test subject intramuscularly (IM) post workout. IGF-1 does not need to be
bilaterally or in the muscle trained.

Unknown whether injecting IGF-1 to
increase muscle growth is efficacious. Many believe in the value of IGF-1.

Growth Hormone Releasing Peptide (GHRP-6)

GHRP-6 (Growth Hormone Releasing Peptide)
Dosing:

Light: 50mcg
Common: 100mcg
Large: 150mcg

Growth
Hormone Releasing Peptide (GHRP-6) is a peptide in the growth factor family
composed of six amino acids. It has strong effect on the release of Human Growth
Hormone (HGH). Dosed at night for anti-aging purposes and multiple times

throughout the day for anabolism. GHRP is often used in conjunction with GHRH
CJC-1295 to amplify GH pulse. GHRP-6 peptide is typically offered in 5mg
vials.

GHRP can be used effectively in the treatment of GH deficiency.
Main use is to promote food intake by stimulating hunger and aid in energy
metabolism. The major side effect being a significant increase in appetite due
to a stimulating the release of Ghrelin, a hormone released naturally in the
lining of the stomach and increases hunger and gastric emptying.

Benefits
of increased HGH levels through GHRP-6 stimulation include: an increase in
strength, muscle mass and body fat loss, rejuvenation and strengthening of
joints, connective tissue and bone mass. Enhanced HGH secretion also leads to
the liver secreting more IGF-1, which is thought to be the primary anabolic
mechanism of action for Growth Hormone.

Mixing: Bacteriostatic water is
used for reconstitution. When diluted, peptide lasts a very long time when left
alone in the refrigerator (months).

Example- 2.5ml(cc) bacteriostatic
water per 5mg GHRP vial equates to a 100mcg dose approximately each 2-3 marks on
a U100 insulin syringe.
Example- 5ml(cc) bacteriostatic water per 5mg GHRP
vial equates to a 100mcg dose approximately every 5 marks on a U100 insulin
syringe.

Dosing: The saturation dose of GHRP-6 has been determined to be
around 100mcg

5mg GHRP = 5,000mcg

5,000mcg/100mcg = 50 100mcg GHRP
doses per 5mg

GHRP-6 may be the most cost effective secretalogue
available today.


Growth Hormone Releasing Hormone
CJC-1295

CJC-1295 Dosing:

Light: 50
mcg
Common: 100 mcg
Large: 250 mcg

Growth Hormone Releasing Hormone
(GHRH) CJC-1295 is a synthetic secretalogue, when injected stimulates HGH
release from the hypothalamus. Dosing GHRH once at night for anti-aging purposes
and multiple injections (1-3x) for anabolism. CJC-1295 has the ability to make
the body produce its own GH as compared to using synthetic HGH. GHRP-6 use in
conjunction with CJC-1295 is synergistic, amplifying the GH pulse
considerably.

CJC-1295 is typically found in 2mg vials. Reconstitute with
BW. Inject subcutaneously.

Researchers report positive effects much like
that of HGH. Particularly energy, quality sleep, fat loss/metabolism, improved
skin quality, pumps in the gym.

Most common desirable form to find and
research with CJC-1295 (Growth Hormone Releasing Factor) is a modified GRF
(1-29), lacking the DAC (drug affinity complex). This GHRH has a short half
life. Post injection flush is common.”

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