Tag Archive for Insulin

Insulin Facts!

Insulin Facts!
Ok, lets have a look at insulin.
Its highly anabolic and non-androgenic, and in case some of you are in the dark (I’d like to think we’re all clear on anabolic versus androgenic, but ya never know) I’ll briefly touch on the subject before diving in… if youre ok on anabolic/androgenic concepts, skip to the INSULIN part…


ANABOLIC is defined as “The process of constructive metabolism” or of building complex substances out of simple substances.
The way your body processes protien, carbohydrates, and fat (all simple substances) and makes muscle (a complex substance) is ANABOLISM.

ANDROGENIC is basically defined as pertaining to male sex characteristics.


“Steroids” are actually called “Anabolic Androgenic Steroids.” They accomplish “anabolism” through “anabolic” pathways, some being more androgenic (testosterone esters) and some less (winstrol, anavar, primobolan, ect…).
Most often, with reduced androgenic properties comes reduced anabolic properties, but it isnt always cut and dry. If anyone is interested I’ll go into it another time, but lets head toward the insulin topic.

INSULIN: NonAndrogenic but Anabolic

Insulin is NOT a sex hormone. It is not related in any way to testosterone, or to estrogen for that matter. It is a product of the pancreas as opposed to testosterone which is a product of the HPTA, pituitary, gonadal, leydig, mishmash of interconnected glands…


So why is insulin anabolic then? Insulin is a partitioning agent. A “shuttle” if you will.
Picture insulin as a bus. Nutrients board the bus, and insulin pulls away and drops off the nutrients at the proper bus stop. That is basically what it does, and for all intents and purposes that is everything you need to know to understand how it works.
So by insulin shuttling these nutrient where they need to go, it enables anabolism and is therefor anabolic!


Well, the amount of carbs you would need to take in to increase natural insulin levels to the degree a 10 i.u. shot would would be far more dangerous than using insuiln (and using insulin is NOT that hard OR dangerous).
Carbs at that level would eventually lead to diabetes and fat gains.
If insulin is a bus taking nutrients where they need to go, then exogenous insulin is a bullet train! It can hold far more nutrients than a normal naturally produced burst of insulin can, and it works quicker. Exogenous insulin is the most efficient way to accomplish glycogen overcompensation, period.


Im a major supporter of fast acting insulin. The faster the better!
Currently he fastest acting insulin available is Humalog. It is active in 15 minutes, peaks in 1 hour and clears the system around 2 hours.
Next would be Humalin-R. It is active in about 30 minutes, peaks at the 2 hour mark, and clears the system at the 4 hour mark.
“Biophasics” are mixtures of fast and slow acting insulins, but are not the best choice in my opinion, due to an active dose being in you throughout the day. The reason you dont want that will be covered in the “HOW DO I USE IT” section.
There are also Humalin-L and Humalin-S, but they are long acting, and are no more use to me than the Biophasics. There are also porccine and bovine derived insulin, but I am against injecting animal derived substances.


Im going to assume we want to avoid any fat gains at all. Even bulking I dont like to gain any unneccesary fat, so Im going to disuss it from that stand point.
The ultra conservative time to use insulin is post-workout. Most people who are concerned about fat dont go over 10 i.u. as a total dose.
Some people us it on waking, before breakfast, since your body is in a basically carb depleted state. Its the kind of thng you have to try for yourslef, and if it works for you, do it. If you thnk youre gaining fat, stop. BUT! Dont start it at both times at once. Make sure you get your post workout dosage worked out and that you know it is not causing you any fat gains before you try pre-breakfast shots. That way you can take out all the guess work as to where any fat gains may come from.


There is a commoly held perception that you MUSt take in 10grams of carbs per I.U. of insulin, some radicals say 5 grams… well, theyre both wrong.
I got curious about this when I discovered that my insulin dependant diabetic friend didnt even keep track of what she ate post injection. She would feel hypoglycemic after a shot and take a Glucose Tablet.
A glucose tablet is only 5 grams of glucose (carbs)! So I started to think, “Hmmm, mabye everyone is off point on this?”
After conducting a few experiments on myself, I found that you can go considerably lower in carbs than people previously believed.
Now it doesnt make sense to go low in carbs, because that defies the purpose of using the insulin in the first place, but it does free us from having to use so much that there might be some “spill over” in carbs that cant be utilized. So it really makes us able to have more freedom in carbs choices and amounts.
The “risk” in insulin use is not as risky as people believe. Any person with an ounce of sense can see the warning signs of a problem coming, and remedy the situation.


If you look at the drug store, you can get these little pen cases that hold a loaded insulin syringe. They are great for our need, you load up the syringe, and put it in the case, and throw it in your bag/purse/whatever. After the workout, head to a bathroom stall and inject it under the skin! Pull up a little skin from the abdomen or upper thigh (anywhere will do, but these are easiest) and inject. Do not shoot into a muscle. This rushes the dose and makes it harder to predict when it will spike.
So now you have 15 minutes to get some carbs (actually you have longer, since the initial hit of the dose is mild and easy to cope with, the spike is a little more harsh, but still nothing unbearable. If you use the carbs, you probobly wont notice the initial dose OR the spike.)
(this is based on Humalog at 10 i.u.)
I use a powder with a 20% simple/80% complex ratio (actually its 17% mono, 5% di, 7% tri, 5%tetra, and 66% penta-saccharides). I use about 60grams of carbs to the 10 i.u. of insulin.
This gives me a nice solid stream of carbs to overcompensate my depleted muscles, but not so many that I risk fat accumulation from the excess.
Now you are good to go till around 1 hour after the initial injection. At this 1 hour mark, the majority of the dose hits your system. Now is the time to eat a good balanced (AND FAT FREE!) meal. The fat-free emphasis will be explained in the POTENTIAL PROBLEMS section. This balance meal of carbs and protien and little to know fat can be anything from a protien drink and a crab drink, to a low fat MRP, to some lean chicken and rice… your choice.
After this meal, you dont need to pay anymore consideration to the insulin, it will gradually decrease and will be out of your system at the 2 hour mark.
Till you get accustmed to the use of insulin, start low and slow. Start at 2 i.u. then 5 i.u. then 7 i.u. then 10 i.u. That way you get a better understanding of any hypoglycemia you may encounter. Ive went as high as 35 i.u., just to try it, but at a certain point a higher dosage doesnt yield any better results (except fat!)


Insulin is relativly safe. If you dont take in any carbs after using it, your body will give you PLENNTY of warning! Youll feel dizzy, tired, achey… hypoglycemic. What is happening is your body has no glycogen to use as fuel. Your muscles re depleted from working out, and often times youve tapped your liver for any remaining glycogen. The insulin does, searching for glycogen to use, takes the rest from your liver, and in the absence of carbs coming in to make more, it heads for the brain.
Your brain uses glucose as its primary fuel source (a little fat, too.) Thats why you get dizzy and light headed, the same with during a ketogenic diet… low glucose equals light headedness.
So if you forget about the carbs, youll get a warning from yuor body, and you can get your ass in gear and get some carbs in you.
If you get to the point where youre nauseated, just drink some sugary beverage and get some carbs in you quickly. Youre still a long long way from any major danger, but dont mess around.
“Fat Free” I said earlier about the 1 hour mark meal. During the 2 hours of the dosage duration, you should avoid fat like it is the plauge! Insulins partitioning properties are as effective at sending fat to the fat stores as it is carbs and protien to muscles!
So till the dose is clear of your system, NO FAT! (Thats another reason why I advocate the fastest acting insulin you can get.)

Well, I cant think of anything else off hand that needs to be said, but if I missed anything, just ask. I may have taken somethng for granted and figured everyone would know or assume on their own…


Well, the carbs you take in after the shot are immediatly sent to your muscles to make up for the depleted state your workout put them in. At this point you are able to actually fill them with MORE glycogen than they could hold before the workout. This adds up to extra macro nutrients in the system for repairing the micro fiber damage done to the muscles.
The protien you take in at the 1 hour meal (and you can take in post workout protien shake after the carbs, too) will be preferentially sent where it is needed the most. So you can get those muscles rebuilt faster, and more efficiantly!

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Humalog – fast acting insulin for bodybuilding

Humalog – fast acting insulin for bodybuilding

Humalog Insulin (Fast Acting)
Substance: insulin
Delivery: 10ml vial (40IU/1ml)
Average Dose: 1iu per 15 – 20 pounds bodyweight
Half Life: 1.5 – 3 hours
Water Retention: Yes
DHT Conversion:

Insulin is a powerful hormone in the human body, responsible for regulating glucose levels in the blood. This is a function that your life constantly depends on. Before going any further I must stress that insulin use by those who do not medically require it can be a very risky endeavor. It is important not only to research and understand the risks involved, but to really give some thought to just how important a little extra boost is to you. Misusing insulin can have tragic results. Immediate death, coma or the possible development of insulin dependent diabetes in a previously healthy athlete are all possible, be extremely careful.

In the human body insulin is secreted by the pancreas. The release of this hormone is most closely tied to glucose, although a number of other factors including pancreatic & gastrointestinal hormones, amino acids, fatty acids and ketone bodies are also involved. Its role in the body is to control the uptake, utilization and storage of amino acids, carbohydrates and fatty acids by various cells of your body. The activity of insulin is both anabolic and anti-catabolic, the hormone stimulating the use and retention cellular nutrients while inhibiting their breakdown. Skeletal muscle cells are among the many targets of this hormone’s action, and the reason pharmaceutical insulin has made its way into the realm of athletics. But this is a little tricky because insulin can also promote nutrient storage in fat cells, obviously an unwanted result. Athletes have found however, that a strict regimen of intense weight training and a diet without excess caloric intake can result in insulin showing a much higher affinity for protein and carbohydrate storage in muscle cells. This could produce rapid and noticeable growth, the muscles beginning to look fuller (and sometimes more defined) almost immediately after starting insulin therapy.

The fact that insulin use cannot be detected by urinalysis has ensured it a place in the drug regimens of many professional bodybuilders. Insulin is often used in combination with other “contest safe” drugs like human growth hormone, thyroid medications and low dose testosterone injections, and together can have a dramatic effect on the users physique without fear of a positive urinalysis result. Those who do not have to worry about drug testing however, find insulin and anabolic/androgenic steroids a very synergistic combination. This is because the two actively support an anabolic state through different mechanisms, insulin enhancing the transport of nutrients into muscle cells and steroids (among other things) increasing the rate of cellular protein synthesis.

The actual medical purpose for insulin is to treat different forms of diabetes. Specifically the human body may not be producing insulin (Type-I diabetes) or may not recognize insulin well at the cell site although some level is present in the blood (Type-Il diabetes). Type-I diabetics are therefore required to inject insulin on a regular basis, as they are left without a sufficient level of this hormone. Along with medication, the individual will need to constantly monitor blood glucose levels and regulate their sugar intake. Together with lifestyle modifications such as regular exercise and developing a balanced diet, insulin dependent individuals can live a healthy and full life. Untreated, diabetes can be a fatal disease.

As we have discussed earlier, regular insulin is the most popular choice and will be the subject of our intake discussion. Before one even considers using insulin, they should become very familiar with using a glucometer. This device gives you a quick number reading of your blood glucose level and can be indispensable in helping you manage your insulin/carbohydrate intake.

Insulin is used in a wide variety of ways. The dosages can vary significantly among athletes, and are often dependent upon factors like insulin sensitivity and the use of other drugs. Most users choose to administer insulin immediately after a workout, which is likely the most “anabolic” time of the day to use this drug. Insulin is always injected subcutaneously, or below the surface of the skin but without entering muscle tissue. This is given by pinching a fold of skin, commonly in the arm or abdominal area. A small “insulin needle” is used, approximately ?” long, 27-29 gauge thickness and holding one third to one full cc. These are available over-the-counter in many states. A full cc (or ml) equates to 100 international units (l.U.), a scale that is clearly labeled on an insulin syringe. It is important that the injection site be left alone after insulin has been injected and not rubbed. This is to prevent the drug from releasing into circulation too quickly. It is also a good idea to rotate injection sites regularly; otherwise a localized buildup of subcutaneous fat may develop due to the lipogenic properties of this hormone.

Among bodybuilders, dosages used are usually in the range of 1IU per 15-20 pounds of lean bodyweight. First- time users should at first ignore body weight guidelines however, and instead start at a low dosage with the intention of gradually working up to this point. For example, on the first day of insulin therapy you could begin with a dose as low as only 2 lU. Each consecutive post-workout application this dosage can be increased by 1 IU, until the user determines a comfortable range. This is safer and much more tailored to the individual than simply calculating and injecting a dose, as many find they tolerate much more or less insulin than weight guidelines would dictate. Athletes using growth hormone in particular often have higher insulin requirements, as HGH therapy is shown to both lower secretion of, and induce cellular resistance to, this hormone.

One also must remember that it is very important to consume carbohydrates for several hours following insulin use. One will generally follow the rule-of-thumb, of ingesting at least 10 grams of simple carbohydrates per IU of insulin injected (with a minimum immediate intake of 100 grams regardless of dose). This is timed approximately 20 to 30 minutes after the drug has been administered. The use of a carbohydrate replacement drink such as Ultra FueK by Twin Labs would probably be a good idea, as this is a fast and reliable carbohydrate source. It is best to always have something like this on-hand should you begin to notice too low a drop in glucose levels. Many athletes will also take creatine monohydrate with their carbohydrate drink, since the insulin may help force the creatine into the muscles. An hour or so after injecting insulin, one will eat a good meal or consume a protein shake. The carbohydrate drink and meal/protein shake are absolutely necessary. Without them, blood sugar levels can drop dangerously low, and the athlete will most likely enter a state of hypoglycemia.

Many taking insulin will also notice a tendency to get sleepy some time after injecting the drug. This is an early symptom of hypoglycemia, and a clear sign the user should be consuming more carbohydrates. One should absolutely avoid the temptation to go to sleep at this point, as the insulin may take its peak effect during rest and blood glucose levels could be left to drop significantly. Unaware of this condition during sleep, the athlete may be at a high risk for going into a state of severe hypoglycemia. We have of course already discussed the serious dangers of such a state, and unfortunately here simply consuming more carbohydrates will not be an option. Those experimenting with insulin would therefore be wise to always stay awake for the duration of the drug’s effect, and also avoid using insulin in the early evening to ensure the drug will not be inadvertently active when retiring for the night.

Many athletes prefer to bring their insulin with them to the gym, injecting in the locker room (or car) immediately after a workout. Although insulin should be refrigerated, it is fine to keep it in a gym bag or car so long as it is not left out for too long and it is kept away from heat/direct sunlight. Rather than waiting to the end of a workout, some actually prefer to inject their insulin dosage during training, 30 minutes prior to the end of a session. Immediately following the workout the user will consume a carbohydrate drink in this case. Such timing may make the insulin more efficient at bringing glycogen to the muscles, but also increases the danger of hypoglycemia as carbohydrate consumption may be inadvertently delayed. Some will go so far as to inject a few units before lifting to improve their pump. This practice is risky and best left to those very experienced with insulin. Finally, some bodybuilders opt to inject insulin upon waking in the morning. After the injection they will consume a carbohydrate drink. Later, perhaps one hour after the injection, a full breakfast will be consumed. Some athletes find this application of insulin very beneficial for putting on extra mass while others will tend to store excess fat. If using more than one application of insulin per day it would also be a good idea to restrict the total daily intake to no more than 20-40 IU.

Remember to be very careful, one mistake in dosage or diet can be potentially fatal

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