Tag Archive for peptide use

Ipamorelin Peptide For Building More Muscle

Ipamorelin is a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world. Like the GHRP-6 peptide (growth hormone releasing hexapeptide), it is a synthetic peptide that has powerful Growth Hormone releasing properties. And these GH releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat. Both Ipamorelin and GHRP-6 as well as numerous other peptides and research chemicals can be found at superiorpeptides.com.

Whereas GHRP-6 is a hexapeptide, Ipamorelin is a penta-peptide. (Aib-His-D-2-Nal-D- Phe-Lys-NH2) And, the strength it displays may very well make regular old Growth Hormone (GH) obsolete. But what athletes and bodybuilders really want to know is what is this wonder peptide capable of doing, how is it used, and how does it compare to the other GHRP peptides?

Bodybuilding Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or three times daily, using a tiny insulin needle to inject. They usually start with the lower dose since side effects can include headaches or what feels like a head-rush. Ipamorelin can be taken at anytime but taking it about 30-45 minutes before a workout would seem ideal because of the pulse in Growth Hormone (GH) it creates allowing for maximum growth.

Studies on the effects of Ipamorelin on bone growth, body weight, and GH release showed some interesting conclusions.

In one experiment, various doses were administered over the course of 15 days to test the group’s reactions.

There was a distinct and dose-dependent effect on body weight gain however, the treatment group did not show a change in total IGF-I levels. Nor did the treatment group produce serum markers of bone development. For example, the number of cells in the wide portion of the tibia (the shinbone) did not change significantly. This is a good thing because it suggests muscle growth with less potential for deformity of bone or cartilage.

The reaction of the pituitary to an aggressive i.v. dose of Ipamorelin showed that plasma GH levels were notably reduced whereas they were unchanged after a comparable dose of GHRH. This is actually a good thing as it suggests that Ipamorelin may not decrease your body’s natural GH production – further demonstrating that Ipamorelin is a selective GH releaser.

GHRP-2 Unlike GHRP-6, Ipamorelin does not induce hunger making it advantageous to those on a restricted calorie diet. And obviously, Ipamorelin’s side-effects are enhanced when combined with anabolic steroids since they too influence Growth Hormone/Insulin Growth Factor release and production.

In another study in rats, Ipamorelin released GH from rat pituitary cells as effectively as GHRP-6.

Another document states that in healthy swine, Ipamorelin released GH with a consistency that is very comparable to GHRP-6. Also noteworthy was that none of the GH releasers tested affected FSH, LH, PRL or TSH blood serum plasma levels.

Ipamorelin in theory may increase Acetylchloine or Cortisol when used in higher dosages. However, and increase in Acetylchloine or Cortisol is even more likely with GHRP-2 and GHRP-6. In fact, in the case of Ipamorelin, there was little to no rise in Acetylcholine and Cortisol blood plasma levels even at injections more than 200 times higher than the effective dosage for comparable GH release.

This clearly proves that Ipamorelin is the first successful GHRP receptor agonist or chemical that binds to a receptor of a cell and triggers a response by that cell with a specific selectivity for the promotion of GH release by itself.

Another advantage to Ipamorelin is that it doesn’t cause sudden spikes in prolactin or cortisol as does GHRP-2 and GHRP-6. Ipamorelin is slower in its delivery unlike GHRP’s which spike GH levels at a more rapid rate. The slower release is more natural and has a more sustained effect.

All in all it looks as if Ipamorelin is the new wave in GH releasing peptides. It appear to be more potent, longer lasting and potentially safer to use in the long run. More studies are being conducted all the time but as it stands, Ipamorelin looks like a serious contender in the arsenal of anabolic advancement.

Both bodybuilding peptides Ipamorelin and GHRP-6 as well as numerous other peptides and research chemicals can be found at SuperiorPeptides.com

 

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Human Growth Hormone (HGH)

Human Growth Hormone (HGH)

Human Growth Hormone (HGH) Dosing:

Month 1: HGH 2 IU one injection every other day
Months 2-4: HGH 3 IU one injection five days a week
Months 5-6: HGH 4 IU one injection five days a week
4-6 month cycles are optimal, year round if you are over age 35.

Human Growth Hormone (rHGH, HGH, or GH) is a protein molecule consisting of 191 amino acids. Genetically engineered recombinant human growth hormone is completely identical to the growth hormone made by the human pituitary gland. Researchers have proven growth hormone therapy can reverse the biological effects of aging. HGH is widely appreciated for aesthetics, not necessarily as a performance enhancer.

HGH
is released in pulses that take place during the day. Growth hormone is rapidly converted in the liver to its powerful growth promoting metabolite, Insulin like Growth Factor. IGF-1 is measured in the blood to determine the level of growth hormone secretion. Most of the beneficial effects of human growth hormone are directly attributable to IGF-1. Growth hormone replacement/stimulation is the most effective therapy to reverse the effects of aging.

At age 30 people have people have spent most of their lives with relatively high levels of HGH. HGH is responsible for growth during childhood as well as for repair and regeneration of tissue. By the time we are 30 our bodies no longer naturally produce enough GH to handle the damage that is taking place. As this continues, we age. Increasing HGH in our bodies, we can slow, or even reverse many of the manifestations of aging.

What HGH can do:

* Reduce excess body fat, especially abdominal fat. (The reduction of abdominal fat is the single most profound effect of HGH replacement in many people)
* Decrease in the waist to hip ratio. (Meaning fat is removed primarily from around the waist where it is associated with a high risk of coronary disease)
* Increase muscle mass. (and physical strength if combined with moderate exercise)
* Reduce wrinkling of the skin and some other effects of skin aging. (Compliments can be Melanotan and MT-II)
* Re-grow certain internal organs that have atrophied with age.
* Increase bone density.
* Strengthen the immune system.
* Enhanced feeling of well being.
* Reverse cognitive decline.
* Stimulate production of the bone marrow cells that produce red blood cells.
* Reduce the probability that you will spend the last years of your life in a nursing home.
* HGH slows the progression of cardiovascular disease, and reduces the risk of death from cardiovascular disease, in individuals with natural growth hormone levels that are below average for the age of the individual. HGH can also slow the progression of cardiovascular disease by improving one’s cholesterol profile. There is increasing evidence over the past year or two that maintaining healthy growth hormone levels results in a stronger heart. Individuals with low growth hormone levels have an overall increased risk of death due to cardiovascular disease. Low growth hormone levels cause a particularly large increase in the risk of stroke as compared with individuals receiving growth hormone replacement.

HGH takes several weeks to months of use benefit from its effects. There are a number of substances that increase the natural secretion of HGH. Some of them are amino acids. The relationship of certain amino acids to growth hormone is complex and varies greatly among different individuals and among individuals of different ages. All absolute and universal statements made about this subject are clearly false.

HGH is a peptide that comes in the form of lyophilized powder. Any other form that you see advertised or run across is likely NOT the real deal. The only way to administer true HGH is by sub-q or intramuscular injection. Be aware that HGH is not anabolic by itself. Careful measures need to be in place during reconstitution.

Reconstituting common HGH, one vial contains powdered freeze-dried HGH and the other vial contains sterile water with a bacteriostatic preservative. When the user is ready to begin, a certain amount of the sterile water is drawn out of the second vial (with a needle and syringe) and injected into the first vial to dissolve the powdered HGH. The solution is then ready for injection. The unused portion is to be kept refrigerated. Use reconstituted HGH within 3 or 4 weeks.

HGH peptide is dissolved by the user because HGH powder is much more durable. The dissolved HGH is very susceptible to being attacked by bacteria and degraded by enzymes. HGH is normally refrigerated, but if HGH powder is is left at room temperature for a few hours, no harm is done as long as the room is not too warm. Sterile powdered HGH can even be left in a cool room for days or weeks, but this is not a good idea. Even the powdered HGH can deteriorate if the temperature rises slightly above normal room temperature for any significant period of time.

The best way to begin HGH is to start with a low dose and ease your way into higher doses. This will allow you to avoid (or at least minimize) many of the more common sides of HGH such as bloating and joint pain. Most can tolerate 1-2 IU per day with few sides. HGH administration should be done on an empty stomach as fats and carbohydrates blunt release. Natural production of GH is 1 IU, give or take a half. For results in athletes the dosing should attempt to duplicate how the body releases the hormone naturally. Learning how much and when to best dose is very individual. My apologies for the dosing chart above.

For bodybuilders growth hormone is best taken in conjunction with insulin, anabolics/androgens, and thyroid hormone. Insulin is extremely effective with HGH as the injections cause a down regulation of insulin sensitivity in the body.

Half life of HGH is 2 hours when injected sub-q with a four hour period which there is a suppression of naturally produced GH. Intramuscular injections shorten the half life. Subcutaneous injections over the long term can lead to spot reduction. Whether or not HGH has any localized benefit from IM injection is unknown, but speculated.

HGH is tightly regulated by the FDA, but HGH is not a controlled substance on the federal level in the United States.”

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